Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part II. Treatment, follow-up, and special situations.

Abstract

BACKGROUND:

There are no previous Spanish guidelines or consensus statements on bradykinin-induced angioedema.

AIM:

To draft a consensus statement on the management and treatment of angioedema mediated by bradykinin in light of currently available scientific evidence and the experience of experts. This statement will serve as a guideline to health professionals.

METHODS:

The consensus was led by the Spanish Study Group on Bradykinin-Induced Angioedema, a working group of the Spanish Society of Allergology and Clinical Immunology. A review was conducted of scientific papers on different types of bradykinin-induced angioedema (hereditary and acquired angioedema due to C1 inhibitor deficiency, hereditary angioedema related to estrogens, angioedema induced by angiotensin-converting enzyme inhibitors). Several discussion meetings were held to reach the consensus.

RESULTS:

Treatment approaches are discussed, and the consensus reached is described. Specific situations are addressed, namely, pregnancy, contraception, travelling, blood donation, and organ transplantation.

CONCLUSIONS:

A review of and consensus on treatment of bradykinin-induced angioedema is presented.

• Authors: T Caballero, M L Baeza, R Cabañas, A Campos, S Cimbollek, C Gómez-Traseira, T González-Quevedo, M Guilarte, J Jurado-Palomo, J I Larco, M C López-Serrano, M López-Trascasa, C Marcos, J M Muñoz-Caro, M Pedrosa, N Prior, M Rubio, A Sala-Cunill, Spanish Study Group on Bradykinin-Induced Angioedema (SGBA)
• Journal: Journal of investigational allergology & clinical immunology (J Investig Allergol Clin Immunol) Vol. 21 Issue 6 Pg. 422-41; quiz 442-3 ( 2011) ISSN: 1018-9068 [Print] Spain
• PMID: 21995176 (Publication Type: Consensus Development Conference, Journal Article, Review)

Chemical References

• Bradykinin

Topics

• Angioedema (diagnosis, metabolism, therapy)
• Bradykinin (antagonists & inhibitors, metabolism)
• Humans
• Prognosis