Abstract | OBJECTIVE: PREDICTIVE (Predictable Results and Experience in Diabetes through Intensification and Control to Target: an International Variability Evaluation) is a large, multinational, open-label, prospective, observational study addressed to assess the efficacy and safety of insulin detemir in clinical practice. This paper reports 26 weeks of follow-up data, from 1298 type 2 diabetes patients from Italy. RESEARCH DESIGN AND METHODS: RESULTS:
Insulin detemir significantly improved glycemic control, with a decrease in mean HbA1c, fasting glucose and within-patient fasting glucose variability. Interestingly, the improvements in glycemic control occurred in association with a small, but significant reduction in weight. The safety results of this study showed that 26 weeks of treatment with insulin detemir was associated with a very low rate of SADRs (only 14 events), which mainly consisted of hypoglycemia (78%, of which 42% were major hypoglycemia). CONCLUSIONS:
|
Authors | Gabriele Perriello, Salvatore Caputo, Giovanni De Pergola, Alberto Di Carlo, Giorgio Grassi, Annunziata Lapolla, Pietro Pata, Sebastiano Bruno Solerte, Francesco Zaccardi |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 12
Issue 16
Pg. 2449-55
(Nov 2011)
ISSN: 1744-7666 [Electronic] England |
PMID | 21988213
(Publication Type: Clinical Trial, Clinical Trial, Phase IV, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin, Long-Acting
- hemoglobin A1c protein, human
- Insulin Detemir
|
Topics |
- Adult
- Aged
- Blood Glucose Self-Monitoring
- Body Weight
(drug effects)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Hypoglycemia
(blood, prevention & control)
- Hypoglycemic Agents
(adverse effects, therapeutic use)
- Insulin Detemir
- Insulin, Long-Acting
(adverse effects, therapeutic use)
- Italy
- Male
- Middle Aged
- Young Adult
|