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Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix.

Abstract
Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59-year-old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor.
AuthorsNaoto Kuroda, Yukari Wada, Kaori Inoue, Masahiko Ohara, Keiko Mizuno, Makoto Toi, Azusa Tanaka, Yoji Wani, Hiroyuki Yanai
JournalDiagnostic cytopathology (Diagn Cytopathol) Vol. 41 Issue 7 Pg. 636-9 (Jul 2013) ISSN: 1097-0339 [Electronic] United States
PMID21987295 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2011 Wiley Periodicals, Inc.
Chemical References
  • CD56 Antigen
  • Synaptophysin
Topics
  • Acanthoma (metabolism, pathology)
  • CD56 Antigen (metabolism)
  • Carcinoma, Endometrioid (metabolism, pathology)
  • Carcinoma, Neuroendocrine (metabolism, pathology)
  • Carcinoma, Small Cell (metabolism, pathology)
  • Female
  • Humans
  • Middle Aged
  • Neoplasms, Multiple Primary
  • Synaptophysin (metabolism)
  • Uterine Cervical Neoplasms (metabolism, pathology)
  • Vaginal Smears (methods)

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