Abstract | UNLABELLED:
Coffee caffeine consumption (CC) is associated with reduced hepatic fibrosis in patients with chronic liver diseases, such as hepatitis C. The association of CC with nonalcoholic fatty liver disease ( NAFLD) has not been established. The aim of this study was to correlate CC with the prevalence and severity of NAFLD. Patients involved in a previously published NAFLD prevalence study, as well as additional NASH patients identified in the Brooke Army Medical Center Hepatology clinic, were queried about their caffeine intake. A validated questionnaire for CC was utilized to assess for a relationship between caffeine and four groups: ultrasound negative (controls), bland steatosis/not-NASH, NASH stage 0-1, and NASH stage 2-4. A total of 306 patients responded to the CC questionnaire. Average milligrams of total caffeine/ coffee CC per day in controls, bland steatosis/not-NASH, NASH stage 0-1, and NASH stage 2-4 were 307/228, 229/160, 351/255, and 252/152, respectively. When comparing patients with bland steatosis/not-NASH to those with NASH stage 0-1, there was a significant difference in CC between the two groups (P = 0.005). Additionally, when comparing patients with NASH stage 0-1 to those with NASH stage 2-4, there was a significant difference in coffee CC (P = 0.016). Spearman's rank correlation analysis further supported a negative relationship between coffee CC and hepatic fibrosis (r = -0.215; P = 0.035). CONCLUSION:
Coffee CC is associated with a significant reduction in risk of fibrosis among NASH patients.
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Authors | Jeffrey W Molloy, Christopher J Calcagno, Christopher D Williams, Frances J Jones, Dawn M Torres, Stephen A Harrison |
Journal | Hepatology (Baltimore, Md.)
(Hepatology)
Vol. 55
Issue 2
Pg. 429-36
(Feb 2012)
ISSN: 1527-3350 [Electronic] United States |
PMID | 21987293
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 American Association for the Study of Liver Diseases. |
Chemical References |
- Coffee
- Glycated Hemoglobin A
- hemoglobin A1c protein, human
- Caffeine
- Alanine Transaminase
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Topics |
- Age Factors
- Alanine Transaminase
(blood)
- Body Mass Index
- Caffeine
(administration & dosage)
- Coffee
- Fatty Liver
(blood, complications, pathology)
- Female
- Glycated Hemoglobin
(metabolism)
- Homeostasis
- Humans
- Insulin Resistance
- Liver
(drug effects, pathology)
- Liver Cirrhosis
(blood, etiology, pathology)
- Logistic Models
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- Sex Factors
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