Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - a pilot study.

Abstract

OBJECTIVES:

The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies.

DESIGN AND METHODS:

Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied together in 165 women in third trimester pregnancies complicated with threatening preterm labor (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls.

RESULTS:

Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p=0.007).

CONCLUSION:

Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. However, further study with larger groups of preeclamptic patients is needed to confirm our results.

• Authors: Alexandra Muravská, Anna Germanová, Marie Jáchymová, Zdeněk Hájek, Jana Svarcová, Tomáš Zima, Marta Kalousová
• Journal: Clinical biochemistry (Clin Biochem) Vol. 44 Issue 17-18 Pg. 1380-4 (Dec 2011) ISSN: 1873-2933 [Electronic] United States
• PMID: 21986593 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Chemical References

• Pregnancy-Associated Plasma Protein-A

Topics

• Adult
• Analysis of Variance
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Association Studies
• Genotype
• Humans
• Pilot Projects
• Polymorphism, Single Nucleotide
• Pre-Eclampsia (genetics)
• Pregnancy
• Pregnancy-Associated Plasma Protein-A (genetics, metabolism)
• Risk Factors
• Sequence Analysis, DNA