HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Antioxidant-rich date palm fruit extract inhibits oxidative stress and nephrotoxicity induced by dimethoate in rat.

Abstract
Recent investigations have proved the crucial role of nutritional antioxidants to prevent the damage caused by toxic compounds. In this study, the antioxidant effect of date palm fruit extract on dimethoate-induced oxidative stress and nephrotoxicity in rat is investigated and compared with the effect of the well-known antioxidant vitamin C. Male Wistar rats were randomly divided into six groups of ten each: a control group (C), a group that received dimethoate (20 mg/kg body weight) (D), a group given Deglet Nour extract (DNE), a group treated with DNE 30 min before the administration of dimethoate (DNE + D), a group which received VitC (100 mg/kg body weight) plus dimethoate (Vit C + D), and a group given dimethoate for the first month and DNE 30 min after administration of dimethoate, during the second month (D + DNE). These components were daily administered by gavage for 2 months. After completing the treatment period, blood samples from rats were collected under inhaled diethyl ether anesthesia for serum urea, uric acid, and creatinine levels, while the rat kidneys were obtained for enzyme assays and histology. Oral administration of dimethoate in rats induced a marked renal failure characterized by a significant increase in serum creatinine and urea levels (p < 0.01) in addition to a significant decrease in serum uric acid (p < 0.05). Interestingly, these drastic modifications were accompanied by a marked enhancement of lipid peroxidation in kidney, indicating a significant induction of oxidative damage (p < 0.01) and dysfunctions of enzymatic antioxidant defenses. These biochemical alterations were also accompanied by histological changes in kidney revealed by a narrowed Bowman's space, tubular degeneration, tubular cell desquamation, and tubular dilatation of proximal tubules. Treatment with date palm fruit extract (Deglet Nour) and also with vitamin C significantly (p < 0.05) reversed the serum renal markers to their near-normal levels when compared with dimethoate-treated rats. In addition, Deglet Nour extract and vitamin C significantly reduced lipid peroxidation, restored the antioxidant defense enzymes in the kidney, and improved the histopathology changes. The present findings indicate that in vivo date palm fruit may be useful for the prevention of oxidative stress-induced nephrotoxicity.
AuthorsEmna Behija Saafi-Ben Salah, Amira El Arem, Mouna Louedi, Mongi Saoudi, Abdelfattah Elfeki, Abdelfattah Zakhama, Mohamed Fadhel Najjar, Mohamed Hammami, Lotfi Achour
JournalJournal of physiology and biochemistry (J Physiol Biochem) Vol. 68 Issue 1 Pg. 47-58 (Mar 2012) ISSN: 1877-8755 [Electronic] Spain
PMID21983806 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Plant Extracts
  • Uric Acid
  • Urea
  • Creatinine
  • Ascorbic Acid
  • Dimethoate
Topics
  • Animals
  • Antioxidants (pharmacology, therapeutic use)
  • Arecaceae (chemistry)
  • Ascorbic Acid (pharmacology, therapeutic use)
  • Creatinine (blood)
  • Dimethoate
  • Fruit (chemistry)
  • Kidney (drug effects, enzymology, pathology)
  • Kidney Cortex Necrosis (chemically induced, metabolism, pathology, prevention & control)
  • Male
  • Organ Size (drug effects)
  • Oxidation-Reduction
  • Oxidative Stress (drug effects)
  • Plant Extracts (pharmacology, therapeutic use)
  • Rats
  • Rats, Wistar
  • Urea (blood)
  • Uric Acid (blood)
  • Weight Gain (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: