Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERα-positive endometrioid adenocarcinoma.

Abstract

This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targeting potential of miR-206. Functional analyses of miR-206 were performed in EEC cell lines. MiRNA-206 expression decreased in ERα-positive EECs, and its expression was negatively correlated with ERα. MiRNA-206 overexpression inhibited ERα-dependent proliferation, impaired invasiveness and induced cell cycle arrest of ERα-positive EEC cell lines. Therefore, aberrantly expressed miRNA-206 may be associated with the development of ERα-positive EEC.

• Authors: Xiaoyue Chen, Qin Yan, Shuangdi Li, Long Zhou, Huajing Yang, Yixia Yang, Xuelian Liu, Xiaoping Wan
• Journal: Cancer letters (Cancer Lett) Vol. 314 Issue 1 Pg. 41-53 (Jan 01 2012) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 21983130 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• ESR1 protein, human
• Estrogen Receptor alpha
• MIRN206 microRNA, human
• MicroRNAs

Topics

• Adult
• Carcinoma, Endometrioid (chemistry, pathology)
• Cell Line, Tumor
• Cell Proliferation
• Endometrial Neoplasms (chemistry, pathology)
• Estrogen Receptor alpha (analysis, genetics, physiology)
• Female
• Humans
• MicroRNAs (physiology)
• Middle Aged
• Neoplasm Invasiveness