Synergistic effect of EMF-BEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma.

Abstract

We have investigated the effects of low-frequency pulsed electromagnetic field (LF-EMF) produced by BEMER device on experimental mouse T-cell lymphoma EL4 growing on conventional and/or athymic (nude) mice. Exposure to EMF-BEMER slowed down the growth of tumor mass and prolonged the survival of experimental animals. The effect was more pronounced in immuno-compromised nude mice compared to conventional ones. Acceleration of tumor growth was never observed. No measurable levels of Hsp 70 or increased levels of specific anti-EL4 antibodies were detected in the serum taken from experimental mice before and at different intervals during the experiment, i.e. before solid tumor appeared, at the time of its aggressive growth, and at the terminal stage of the disease. A significant synergizing antitumor effect was seen when EL4 tumor-bearing mice were simultaneously exposed to EMF-BEMER and treated with suboptimal dose of synthetic HPMA copolymer-based doxorubicin, DOX(HYD)-HPMA. Such a combination may be especially useful for heavily treated patients suffering from advanced tumor and requiring additional aggressive chemotherapy which, however, at that time could represent almost life-threatening way of medication.

• Authors: Blanka Říhová, Tomáš Etrych, Milada Šírová, Jakub Tomala, Karel Ulbrich, Marek Kovář
• Journal: Journal of drug targeting (J Drug Target) Vol. 19 Issue 10 Pg. 890-9 (Dec 2011) ISSN: 1029-2330 [Electronic] England
• PMID: 21981636 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• HSP70 Heat-Shock Proteins
• Polymethacrylic Acids
• doxorubicin-N-(2-hydroxypropyl)methacrylamide copolymer conjugate
• Doxorubicin

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage, pharmacology)
• Combined Modality Therapy
• Dose-Response Relationship, Drug
• Doxorubicin (administration & dosage, analogs & derivatives, pharmacology)
• Electromagnetic Fields
• Female
• HSP70 Heat-Shock Proteins (metabolism)
• Immunocompromised Host
• Lymphoma, T-Cell (pathology, therapy)
• Mice
• Mice, Inbred C57BL
• Mice, Nude
• Polymethacrylic Acids (administration & dosage, pharmacology)
• Survival Rate