Abstract | BACKGROUND: SUBJECTS AND METHODS: Plasma PLTP activity (using a phospholipid vesicles-HDL system), PLTP gene score [number of PLTP activity-decreasing alleles based on two tagging polymorphisms (rs378114 and rs60- 65904)] and waist circumference were determined in two Dutch cohorts comprising 237 patients with type 2 diabetes and 78 control subjects. RESULTS: Patients with diabetes were more obese (P < 0.001 for prevalence of increased waist circumference) and had 13% higher plasma PLTP activity (P < 0.001). PLTP gene score was not different in diabetic and control subjects (P = 0.40). PLTP activity was highest in patients with diabetes with an enlarged waist and lowest in control subjects with a normal waist circumference (P < 0.001). Multiple linear regression analysis revealed a positive interaction between diabetes status and waist circumference on PLTP activity (β = 0.200, P = 0.005). Furthermore, diabetes status (β = -0.485, P = 0.046) or HbA1c (β = -0.240, P = 0.035) interacted with PLTP gene score to affect PLTP activity. CONCLUSIONS:
Type 2 diabetes and enlarged waist circumference interact to impact on plasma PLTP activity. Diabetes may also amplify the association between plasma PLTP activity and common PLTP gene variations. Our findings support the hypothesis that diabetes-environment and diabetes-gene interactions govern plasma PLTP activity.
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Authors | R P F Dullaart, M Vergeer, R de Vries, P J W H Kappelle, G M Dallinga-Thie |
Journal | Journal of internal medicine
(J Intern Med)
Vol. 271
Issue 5
Pg. 490-8
(May 2012)
ISSN: 1365-2796 [Electronic] England |
PMID | 21973210
(Publication Type: Journal Article)
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Copyright | © 2011 The Association for the Publication of the Journal of Internal Medicine. |
Chemical References |
- Biomarkers
- Cholesterol, HDL
- Glycated Hemoglobin A
- PLTP protein, human
- Phospholipid Transfer Proteins
- Triglycerides
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Topics |
- Aged
- Biomarkers
- Cardiovascular Diseases
(epidemiology, etiology, metabolism)
- Cholesterol, HDL
(metabolism)
- Diabetes Mellitus, Type 2
(complications, epidemiology, genetics, metabolism)
- Female
- Gene-Environment Interaction
- Glycated Hemoglobin
(metabolism)
- Humans
- Lipid Metabolism
- Male
- Middle Aged
- Netherlands
- Obesity
(complications, diagnosis, epidemiology, genetics, metabolism)
- Phospholipid Transfer Proteins
(blood, genetics)
- Polymorphism, Genetic
- Prevalence
- Risk Factors
- Transcription, Genetic
- Triglycerides
(metabolism)
- Waist Circumference
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