Abstract |
Transgenic mouse technology has gained recognition as an important tool for examining many fundamental biological questions in vivo. Recently, transgenic mouse techniques have been applied to the study of type I ( insulin-dependent) diabetes. These studies have been particularly informative in elucidating 1) mechanisms whereby immune tolerance is maintained to antigens on rare specialized cells such as the pancreatic beta-cell, 2) disease susceptibility and resistance genes, and 3) potentially important immune effector mechanisms. In this article, we discuss these studies, their impact on understanding of the pathogenesis of type I diabetes, and the potential of the transgenic mouse approach for future research.
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Authors | M A Lipes, G S Eisenbarth |
Journal | Diabetes
(Diabetes)
Vol. 39
Issue 8
Pg. 879-84
(Aug 1990)
ISSN: 0012-1797 [Print] United States |
PMID | 2197138
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
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Topics |
- Animals
- Diabetes Mellitus, Type 1
(etiology, genetics, immunology)
- Disease Models, Animal
- Mice
- Mice, Transgenic
(genetics, immunology)
- Prospective Studies
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