The purpose of this paper was to evaluate the efficacy of topical skin
lipid complex (SLC) in canine
atopic dermatitis (AD). Eight dogs with chronic AD and no improvement of main
therapy in symptoms,
erythema, lichenification, excoriation, and
alopecia in the previous month were treated with SLC topically as adjunct
therapy at lesion sites twice weekly for 12 weeks. A statistically significant reduction (26.0%, P < 0.05) in the third version of the Canine
Atopic Dermatitis Extent and Severity Index (CADESI-03) modification from baseline was recorded 6 weeks
after treatment, with marked reduction in the
erythema subscore (36.2%, P < 0.005). A significant reduction in excoriation and
alopecia subscores was observed 6 weeks
after treatment (39.9%, P < 0.05 and 19.9%, P < 0.05, resp.). However, the lichenification subscore was not reduced significantly at 6 or 12 weeks. These findings suggest that topical SLC may have therapeutic and clinical benefits in dogs with AD.