Abstract | BACKGROUND:
Nicotinic acid is an effective treatment for dyslipidemia. Patients are more tolerant of the extended-release form of nicotinic acid because it has a lower incidence of side effects, such as facial flushing, than the immediate-release formulation. OBJECTIVE: METHODS: RESULTS: Twenty-five patients (24% males; mean [SD] age, 57.4 [6.9] years) comprised the treatment group, and 22 patients (5% males; mean [SD] age 61.8 [8.3] years) comprised the placebo group. After 8 weeks of treatment, HDL-C levels were increased significantly in the treatment group (17.6% vs -1.7%, respectively, from 35 [7] mg/dL to 42 [11] mg/dL in the treatment group and from 38 [6] mg/dL to 36 [7] mg/dL in the placebo group; P < 0.001). LDL-C levels were decreased significantly in the treatment group (-11.4% vs 3.6%, respectively, from 147 [33] mg/dL to 126 [22] mg/dL in the treatment group and from 146 [31] mg/dL to 148 [26] mg/dL in the placebo group; P = 0.003). The incidence of drug-related adverse events, including facial flushing in the treatment group, was not significantly different from that in the placebo group. CONCLUSIONS:
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Authors | Sang-Hyun Kim, Min-Kyung Kim, Hae-Young Lee, Hyun-Jae Kang, Yong-Jin Kim, Byung-Joo Park, Hyo-Soo Kim |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 33
Issue 10
Pg. 1357-64
(Oct 2011)
ISSN: 1879-114X [Electronic] United States |
PMID | 21955937
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier HS Journals, Inc. All rights reserved. |
Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Delayed-Action Preparations
- Hypolipidemic Agents
- Niacin
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Topics |
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Delayed-Action Preparations
- Double-Blind Method
- Dyslipidemias
(blood, diet therapy, drug therapy)
- Female
- Flushing
(chemically induced)
- Humans
- Hypolipidemic Agents
(administration & dosage, adverse effects, therapeutic use)
- Male
- Middle Aged
- Niacin
(administration & dosage, adverse effects, therapeutic use)
- Prospective Studies
- Republic of Korea
- Treatment Outcome
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