[Immunization against human malaria: present knowledge].

Abstract

The authors review different aspects of immunization against malaria according to the different stages of the parasitic cycle of Plasmodium falciparum: sporozoite vaccine preventing organism infestation, merozoïte vaccine and gametocyte vaccines preventing the accomplishment of the sexual cycle. Progress of molecular biology and better knowledge of cellular immunity provide some prospects regarding parasitic vaccinology, thanks to genetic engineering. Recombinant vaccines in vitro, in vivo and synthetized are under study and provide the best prospects regarding immunization against human malaria.

• Authors: F Peyron, B Oury, Ambroise-Thomas
• Journal: Medecine tropicale : revue du Corps de sante colonial (Med Trop (Mars)) 1990 Jan-Mar Vol. 50 Issue 1 Pg. 137-41 ISSN: 0025-682X [Print] France
• Vernacular Title: La vaccination antipaludique, où en est-on?
• PMID: 2195280 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Vaccines, Synthetic

Topics

• Animals
• Genetic Engineering
• Humans
• Immunity, Cellular (physiology)
• Immunization (methods, trends)
• Malaria (immunology, prevention & control)
• Plasmodium falciparum (growth & development)
• Vaccines, Synthetic (therapeutic use)