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Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese.

Abstract
Folate consumption is inversely associated with the risk of oral and pharyngeal cancer (OPC) and potentially interacts with alcohol drinking in the risk of OPC. Aldehyde dehydrogenase 2 (ALDH2) gene polymorphism is known to interact with alcohol consumption. The aim of this study was to investigate potential interaction between folate, alcohol drinking, and ALDH2 polymorphism in the risk of OPC in a Japanese population. The study group comprised 409 head and neck cancer cases and 1227 age-matched and sex-matched noncancer controls; of these, 251 cases and 759 controls were evaluated for ALDH rs671 polymorphism. Associations were assessed by odds ratios and 95% confidence intervals in multiple logistic regression models. We observed an inverse association between folate consumption and OPC risk. The odds ratio for high folate intake was 0.53 (95% confidence interval: 0.36-0.77) relative to low intake (P trend=0.003). This association was consistent across strata of sex, age, smoking, and ALDH2 genotypes. Interaction between folate consumption, drinking, and ALDH2 genotype was remarkable (three-way interaction, P<0.001). We observed significant interaction among folate, drinking, and ALDH2 genotype in the Japanese population.
AuthorsKeitaro Matsuo, Marta Rossi, Eva Negri, Isao Oze, Satoyo Hosono, Hidemi Ito, Miki Watanabe, Yasushi Yatabe, Yasuhisa Hasegawa, Hideo Tanaka, Kazuo Tajima, Carlo La Vecchia
JournalEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) (Eur J Cancer Prev) Vol. 21 Issue 2 Pg. 193-8 (Mar 2012) ISSN: 1473-5709 [Electronic] England
PMID21946912 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Folic Acid
  • ALDH2 protein, human
  • Aldehyde Dehydrogenase
  • Aldehyde Dehydrogenase, Mitochondrial
Topics
  • Adult
  • Aged
  • Alcohol Drinking (adverse effects, epidemiology)
  • Aldehyde Dehydrogenase (genetics)
  • Aldehyde Dehydrogenase, Mitochondrial
  • Asian People (genetics, statistics & numerical data)
  • Carcinoma (epidemiology, ethnology, etiology, genetics)
  • Carcinoma, Squamous Cell (epidemiology, ethnology, etiology)
  • Case-Control Studies
  • Eating (physiology)
  • Female
  • Folic Acid (administration & dosage)
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease
  • Head and Neck Neoplasms (epidemiology, ethnology, etiology)
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms (epidemiology, ethnology, etiology, genetics)
  • Pharyngeal Neoplasms (epidemiology, ethnology, etiology, genetics)
  • Polymorphism, Single Nucleotide (physiology)
  • Risk Factors
  • Squamous Cell Carcinoma of Head and Neck
  • Young Adult

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