HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Long-term outcome of proton beam radiosurgery for arteriovenous malformations larger than 30 mm in diameter.

Abstract
The effectiveness of proton beam (PB) radiosurgery for large lesions is greater than for other treatment modalities. At our institute, PB radiosurgery is used to treat arteriovenous malformations (AVMs). We report the outcome of PB radiosurgery for AVMs over a period of 15 years, focusing on the efficacy of PB radiosurgery combined with embolization for AVMs ≥30 mm in diameter. We retrospectively analyzed 11 patients with AVMs ≥30 mm in diameter who were treated with PB radiosurgery between June 1990 and September 2005 at the Proton Medical Research Center of the University of Tsukuba. The mean irradiation dose was 25.3 gray-equivalent, and the mean duration of clinical follow up was 134.2 months (median 138 months). Pre-radiosurgical embolization was performed in all cases. Complete obliteration was achieved in 9 of the 11 patients. One patient experienced post-radiosurgical hemorrhage, and 1 patient experienced radiation-related aggravation of clinical symptoms due to radiation necrosis. Eight patients had excellent outcomes. The multimodal therapy approach of combining pre-radiosurgical embolization and PB radiosurgery for AVMs yielded a favorable outcome for AVMs ≥30 mm in diameter. Thus, PB radiosurgery is a viable treatment option for AVMs ≥30 mm in diameter.
AuthorsYoshiro Ito, Toshiyuki Okumura, Kensuke Suzuki, Akira Matsumura, Koichi Tokuue, Koji Tsuboi
JournalNeurologia medico-chirurgica (Neurol Med Chir (Tokyo)) Vol. 51 Issue 9 Pg. 624-9 ( 2011) ISSN: 1349-8029 [Electronic] Japan
PMID21946724 (Publication Type: Journal Article)
Chemical References
  • Protons
Topics
  • Adolescent
  • Adult
  • Child
  • Combined Modality Therapy (methods)
  • Embolization, Therapeutic (methods)
  • Female
  • Humans
  • Intracranial Arteriovenous Malformations (complications, pathology, therapy)
  • Male
  • Middle Aged
  • Proton Therapy
  • Radiation Dosage
  • Radiation Injuries (epidemiology)
  • Radiosurgery (adverse effects, methods)
  • Retrospective Studies
  • Time
  • Treatment Outcome
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: