Effect of 3-month repeated administration of miglitol on vascular endothelial function in patients with diabetes mellitus and coronary artery disease.

Abstract

Repeated postprandial hyperglycemia may play an important role in the development of atherosclerosis by suppressing vascular endothelial function. Although miglitol suppresses the elevation of blood glucose levels shortly after a meal more than other α-glucosidase inhibitors, the effect of 3-month repeated administration of miglitol on endothelial dysfunction is unknown. Fifty patients with type 2 diabetes and coronary artery disease were enrolled in the present study. The patients were randomly divided into 2 groups, the first treated with miglitol and the second with voglibose for 3 months. Blood chemistry (lipid and blood glucose profiles, glycosylated hemoglobin, 1,5-anhydroglucitol, serum insulin levels, and C-reactive protein) and flow-mediated dilatation were measured at the beginning and end of the trial period. Patient characteristics and blood chemistry of the 2 groups were similar at the beginning of the trial. At the end of the trial, glycosylated hemoglobin decreased in the 2 groups, but the improvements in 1,5-anhydroglucitol in the miglitol group were significantly higher than in the voglibose group. Insulin resistance index, C-reactive protein, and percentage flow-mediated dilatation were also improved in the miglitol group but not in the voglibose group. In conclusion, 3-month repeated administration of miglitol improved vascular endothelial dysfunction by strongly suppressing postprandial hyperglycemia. Miglitol may have antiatherogenic effects in patients with type 2 diabetes and coronary artery disease.

• Authors: Takuo Emoto, Takahiro Sawada, Megumi Hashimoto, Hiroko Kageyama, Daisuke Terashita, Taiji Mizoguchi, Takao Mizuguchi, Yoshiki Motodi, Masamichi Iwasaki, Kazuki Taira, Hiroshi Okamoto, Yosuke Matsuo, Sushi-ku Kim, Akira Takarada, Mitsuhiro Yokoyama
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 109 Issue 1 Pg. 42-6 (Jan 01 2012) ISSN: 1879-1913 [Electronic] United States
• PMID: 21944671 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Blood Glucose
• Glycoside Hydrolase Inhibitors
• Hypoglycemic Agents
• miglitol
• 1-Deoxynojirimycin

Topics

• 1-Deoxynojirimycin (administration & dosage, analogs & derivatives)
• Administration, Oral
• Adult
• Aged
• Aged, 80 and over
• Blood Glucose (drug effects, metabolism)
• Brachial Artery (diagnostic imaging, drug effects, physiopathology)
• Coronary Artery Disease (blood, complications, physiopathology)
• Diabetes Mellitus, Type 2 (drug therapy, physiopathology)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Electrocardiography
• Endothelium, Vascular (drug effects, physiopathology)
• Female
• Follow-Up Studies
• Glycoside Hydrolase Inhibitors
• Humans
• Hypoglycemic Agents (administration & dosage)
• Male
• Middle Aged
• Prospective Studies
• Time Factors
• Treatment Outcome
• Ultrasonography
• Vasodilation (drug effects)