Abstract | PURPOSE: MATERIALS AND METHODS: Seven boys underwent autologous myoblast transplantation between May and December 2006. All patients had persistent urinary incontinence after bladder neck reconstruction and bulking agent injection. Patients were followed for 4 years after autologous myoblast transplantation regarding clinical outcomes and cystometric, urodynamic, uroflowmetric and urethrocystoscopic evaluations. Health related quality of life was also measured before treatment and at final followup. RESULTS: No evidence of urinary obstruction was observed. Five children (71%) were completely continent and 2 (29%) were socially dry with complete daytime dryness at final followup. Health related quality of life was improved significantly. Urodynamic studies revealed a progressive increase in bladder capacity (p <0.001). Mean detrusor leak point pressure showed a 27 cm H(2)O (158%) increase during 4-year followup. Uroflowmetry parameters of voided volume and average maximum flow rate were improved significantly (p <0.001). CONCLUSIONS: The 4-year outcomes demonstrate that autologous myoblast transplantation for urinary incontinence in children with bladder exstrophy- epispadias complex is relatively reliable, reproducible, safe and effective with minimal morbidity. This novel treatment represents a promising therapeutic approach in patients with urinary incontinence. Further randomized trials with larger numbers of patients and longer followup are needed.
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Authors | Azadeh Elmi, Abdol-Mohammad Kajbafzadeh, Ali Tourchi, Saman Shafaat Talab, Shadi Abdar Esfahani |
Journal | The Journal of urology
(J Urol)
Vol. 186
Issue 5
Pg. 2021-6
(Nov 2011)
ISSN: 1527-3792 [Electronic] United States |
PMID | 21944110
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Topics |
- Bladder Exstrophy
(complications, surgery)
- Child
- Epispadias
(complications, surgery)
- Female
- Humans
- Male
- Myoblasts
(transplantation)
- Quality of Life
- Surveys and Questionnaires
- Transplantation, Autologous
- Treatment Outcome
- Urinary Bladder
(surgery)
- Urinary Incontinence
(complications, surgery)
- Urodynamics
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