Abstract | BACKGROUND:
Somatostatinomas are rare neuroendocrine tumours with an annual incidence of 1 in 40 million. They arise in the pancreas or periampullary duodenum. Most are clinically non-secretory and do not cause the somatostatinoma syndrome. Many are metastatic at presentation and their management is typically multimodal. CASE HISTORIES: DISCUSSION: The pathophysiology, presentation, clinical associations and role of diagnostic imaging are discussed for periampullary and pancreatic neuroendocrine tumours. Operative treatment has an important role in both the curative and palliative settings in conjunction with appropriate medical treatments and these are described. Management options depend on the extent of the disease and the cases are used to illustrate the rationale of such strategies.
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Authors | J M L Williamson, C C Thorn, D Spalding, R C N Williamson |
Journal | Annals of the Royal College of Surgeons of England
(Ann R Coll Surg Engl)
Vol. 93
Issue 5
Pg. 356-60
(Jul 2011)
ISSN: 1478-7083 [Electronic] England |
PMID | 21943457
(Publication Type: Case Reports, Journal Article)
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Topics |
- Abdominal Pain
(etiology)
- Adult
- Aged
- Ampulla of Vater
- Cholangiopancreatography, Endoscopic Retrograde
- Cholestasis
(diagnostic imaging, etiology)
- Common Bile Duct Neoplasms
(diagnostic imaging, surgery)
- Diagnosis, Differential
- Female
- Humans
- Incidental Findings
- Jaundice, Obstructive
(diagnostic imaging, etiology)
- Male
- Middle Aged
- Neurofibromatosis 1
(complications)
- Pancreatic Neoplasms
(diagnostic imaging, surgery)
- Pancreaticoduodenectomy
(methods)
- Somatostatinoma
(diagnostic imaging, surgery)
- Tomography, X-Ray Computed
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