Urologic complications among women with advanced cervical cancer at a tertiary referral hospital in Uganda.

Abstract

OBJECTIVE:

To determine the prevalence of and factors associated with urologic complications among women with advanced cervical cancer before treatment in Uganda.

METHODS:

In total, 283 women with histologically confirmed stage IIB-IVB cervical cancer who were admitted to Mulago Hospital over a 6-month period were studied. Abdominopelvic scan was carried out to check for hydronephrosis and hydroureter and to measure the tumor volume. Serum creatinine and urea levels were measured, and the presence of anuria and vesicovaginal fistula (VVF) was ascertained from self-reporting and clinical records.

RESULTS:

Urologic complications were present in 138 (48.8%) women. Hydronephrosis, VVF, hydroureter, and anuria were present in 112 (39.6%), 21 (7.4%), 11 (3.9%), and 9 (3.2%) women, respectively; serum creatinine and urea levels were elevated in 48 (17.0%) women. Stage of disease was significantly associated with urologic complications: stage IIIB odds ratio (OR) 3.36 (95% confidence interval [CI], 1.57-7.20); stage IVA OR 17.10 (95% CI, 6.07-48.16); P<0.001.

CONCLUSION:

There is a high prevalence of urologic complications among women with advanced cervical cancer; these complications are significantly associated with the stage of cervical cancer.

• Authors: Susan Atuhairwe, Robert B Busingye, Musa Sekikubo, Annettee Nakimuli, Twaha Mutyaba
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 115 Issue 3 Pg. 282-4 (Dec 2011) ISSN: 1879-3479 [Electronic] United States
• PMID: 21937039 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Urea
• Creatinine

Topics

• Adult
• Anuria (epidemiology, etiology)
• Creatinine (blood)
• Female
• Humans
• Hydronephrosis (epidemiology, etiology)
• Middle Aged
• Neoplasm Staging
• Prevalence
• Uganda
• Urea (blood)
• Ureteral Diseases (epidemiology, etiology)
• Uterine Cervical Neoplasms (complications, pathology)
• Vesicovaginal Fistula (epidemiology, etiology)