Central auditory dysfunction associated with exposure to a mixture of solvents.

The aim of the present research was to investigate central auditory functioning in normal-hearing, solvent-exposed subjects compared to normal-hearing subjects without solvent exposure, with a comprehensive test battery of behavioural central auditory functioning procedures.
Forty-six normal-hearing, solvent-exposed subjects and 46 normal-hearing, control subjects were selected to participate in the study.
All subjects must present with normal hearing thresholds and absence of history of variables related to the onset of auditory dysfunction. Subjects were evaluated with a test battery comprising pure-tone audiometry (PTA), dichotic digits (DD), pitch pattern sequence (PPS), filtered speech (FS), random gap detection (RGD), masking level difference (MLD), and hearing-in-noise (HINT) tests.
Analyses of covariance (ANCOVA) were performed to compare the mean values of the dependent variables (results for DD, PPS, FS, RGD, MLD, and HINT) between solvent-exposed and control subjects. Age and average hearing thresholds (500-8000 Hz) were included in the analyses as covariates. Significant differences for DD, PPS, FS, and RGD results were found between groups.
This study provides further evidence of the central auditory dysfunction associated with solvent exposure.
AuthorsAdrian Fuente, Bradley McPherson, Louise Hickson
JournalInternational journal of audiology (Int J Audiol) Vol. 50 Issue 12 Pg. 857-65 (Dec 2011) ISSN: 1708-8186 [Electronic] England
PMID21936752 (Publication Type: Journal Article)
Chemical References
  • Solvents
  • Adult
  • Audiometry, Pure-Tone
  • Auditory Diseases, Central (chemically induced)
  • Auditory Threshold
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Solvents (adverse effects)

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