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Central auditory dysfunction associated with exposure to a mixture of solvents.

AbstractOBJECTIVE:
The aim of the present research was to investigate central auditory functioning in normal-hearing, solvent-exposed subjects compared to normal-hearing subjects without solvent exposure, with a comprehensive test battery of behavioural central auditory functioning procedures.
STUDY SAMPLE:
Forty-six normal-hearing, solvent-exposed subjects and 46 normal-hearing, control subjects were selected to participate in the study.
DESIGN:
All subjects must present with normal hearing thresholds and absence of history of variables related to the onset of auditory dysfunction. Subjects were evaluated with a test battery comprising pure-tone audiometry (PTA), dichotic digits (DD), pitch pattern sequence (PPS), filtered speech (FS), random gap detection (RGD), masking level difference (MLD), and hearing-in-noise (HINT) tests.
RESULTS:
Analyses of covariance (ANCOVA) were performed to compare the mean values of the dependent variables (results for DD, PPS, FS, RGD, MLD, and HINT) between solvent-exposed and control subjects. Age and average hearing thresholds (500-8000 Hz) were included in the analyses as covariates. Significant differences for DD, PPS, FS, and RGD results were found between groups.
CONCLUSION:
This study provides further evidence of the central auditory dysfunction associated with solvent exposure.
AuthorsAdrian Fuente, Bradley McPherson, Louise Hickson
JournalInternational journal of audiology (Int J Audiol) Vol. 50 Issue 12 Pg. 857-65 (Dec 2011) ISSN: 1708-8186 [Electronic] England
PMID21936752 (Publication Type: Journal Article)
Chemical References
  • Solvents
Topics
  • Adult
  • Audiometry, Pure-Tone
  • Auditory Diseases, Central (chemically induced)
  • Auditory Threshold
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Solvents (adverse effects)

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