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Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial.

AbstractPURPOSE:
To evaluate the suppressive effect of intravenous dezocine on fentanyl-induced cough during the induction of general anesthesia.
METHODS:
A total of 120 patients, American Society of Anesthesiologists (ASA) physical status I-II, were randomized into two equally sized groups (n = 60). These two groups were given either intravenous dezocine 0.1 mg/kg or a matching placebo (equal volume of 0.9% saline) 10 min before the induction of general anesthesia. Patients were induced with midazolam 0.1 mg/kg, fentanyl 5 μg/kg, propofol 1-1.5 mg/kg, and suxamethonium 1.5 mg/kg. The injection time of fentanyl was less than 2 s in all patients. The occurrence of cough was recorded 2 min after fentanyl bolus.
RESULTS:
No patient in the dezocine group had cough, and 42 patients in the control group had cough. This difference was statistically different between these two groups (P = 0.000).
CONCLUSION:
These results demonstrate that intravenous dezocine 0.1 mg/kg 10 min prior to induction was effective in suppressing fentanyl-induced cough in our patients.
AuthorsZhen-Tao Sun, Chun-Yao Yang, Zhi Cui, Jie Zhang, Xue-Ping Han
JournalJournal of anesthesia (J Anesth) Vol. 25 Issue 6 Pg. 860-3 (Dec 2011) ISSN: 1438-8359 [Electronic] Japan
PMID21935685 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anesthetics, Intravenous
  • Bridged Bicyclo Compounds, Heterocyclic
  • Tetrahydronaphthalenes
  • Fentanyl
  • dezocine
Topics
  • Anesthesia, General (methods)
  • Anesthetics, Intravenous (administration & dosage, adverse effects)
  • Bridged Bicyclo Compounds, Heterocyclic (therapeutic use)
  • Cough (chemically induced, drug therapy)
  • Double-Blind Method
  • Drug Interactions
  • Female
  • Fentanyl (administration & dosage, adverse effects)
  • Humans
  • Male
  • Middle Aged
  • Tetrahydronaphthalenes (therapeutic use)

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