Abstract | PURPOSE: METHODS: A total of 120 patients, American Society of Anesthesiologists (ASA) physical status I-II, were randomized into two equally sized groups (n = 60). These two groups were given either intravenous dezocine 0.1 mg/kg or a matching placebo (equal volume of 0.9% saline) 10 min before the induction of general anesthesia. Patients were induced with midazolam 0.1 mg/kg, fentanyl 5 μg/kg, propofol 1-1.5 mg/kg, and suxamethonium 1.5 mg/kg. The injection time of fentanyl was less than 2 s in all patients. The occurrence of cough was recorded 2 min after fentanyl bolus. RESULTS: No patient in the dezocine group had cough, and 42 patients in the control group had cough. This difference was statistically different between these two groups (P = 0.000). CONCLUSION: These results demonstrate that intravenous dezocine 0.1 mg/kg 10 min prior to induction was effective in suppressing fentanyl-induced cough in our patients.
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Authors | Zhen-Tao Sun, Chun-Yao Yang, Zhi Cui, Jie Zhang, Xue-Ping Han |
Journal | Journal of anesthesia
(J Anesth)
Vol. 25
Issue 6
Pg. 860-3
(Dec 2011)
ISSN: 1438-8359 [Electronic] Japan |
PMID | 21935685
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Intravenous
- Bridged Bicyclo Compounds, Heterocyclic
- Tetrahydronaphthalenes
- Fentanyl
- dezocine
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Topics |
- Anesthesia, General
(methods)
- Anesthetics, Intravenous
(administration & dosage, adverse effects)
- Bridged Bicyclo Compounds, Heterocyclic
(therapeutic use)
- Cough
(chemically induced, drug therapy)
- Double-Blind Method
- Drug Interactions
- Female
- Fentanyl
(administration & dosage, adverse effects)
- Humans
- Male
- Middle Aged
- Tetrahydronaphthalenes
(therapeutic use)
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