Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma.

Abstract

Patients with primary cutaneous melanoma underwent sentinel node (SN) mapping and biopsy at 25 facilities in Japan by the combination of radiocolloid with gamma probe and dye. Technetium-99m ((99m)Tc)-tin colloid, (99m)Tc-phytate, 2% patent blue violet (PBV) and 0.4% indigo carmine were used as tracers. In some hospitals, 0.5% fluorescent indocyanine green, which allows visualization of the SN with an infrared camera, was concomitantly used and examined. A total of 673 patients were enrolled, and 562 cases were eligible. The detection rates of SN were 95.5% (147/154) with the combination of tin colloid and PBV, 98.9% (368/372) with the combination of phytate and PBV, and 97.2% (35/36) with the combination of tin colloid or phytate and indigo carmine. SN was not detected in 12 cases by the combination method, and the primary tumor was in the head and neck in six of those 12 cases. In eight of 526 cases (1.5%), SN was detected by PBV but not by radiocolloid. There were 13 cases (2.5%) in which SN was detected by radiocolloid but not by PBV. In 18 of 36 cases (50%), SN was detected by radiocolloid but not by indigo carmine. Concomitantly used fluorescent indocyanine green detected SN in all of 67 cases. Interference with transcutaneous oximetry by PVB was observed in some cases, although it caused no clinical trouble. Allergic reactions were not reported with any of the tracers. (99m)Tc-tin colloid, (99m)Tc-phytate, PBV and indocyanine green are useful tracers for SN mapping.

• Authors: Hisashi Uhara, Naoya Yamazaki, Minoru Takata, Yuji Inoue, Akihiro Sakakibara, Yasuhiro Nakamura, Keisuke Suehiro, Akifumi Yamamoto, Riei Kamo, Kosuke Mochida, Hideya Takenaka, Toshiharu Yamashita, Tatsuya Takenouchi, Shusuke Yoshikawa, Akira Takahashi, Jiro Uehara, Mikio Kawai, Hiroaki Iwata, Takafumi Kadono, Yoshitaka Kai, Shoichi Watanabe, Satoru Murata, Tetsuya Ikeda, Hidekazu Fukamizu, Toshihiro Tanaka, Naohito Hatta, Toshiaki Saida
• Journal: The Journal of dermatology (J Dermatol) Vol. 39 Issue 4 Pg. 336-8 (Apr 2012) ISSN: 1346-8138 [Electronic] England
• PMID: 21933261 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 Japanese Dermatological Association.

Chemical References

• Coloring Agents
• Fluorescent Dyes
• Organotechnetium Compounds
• Radiopharmaceuticals
• Rosaniline Dyes
• Technetium Compounds
• Tin Compounds
• technetium Tc 99m tin colloid
• technetium phytate
• Technetium
• Phytic Acid
• sulfan blue
• Indocyanine Green

Topics

• Coloring Agents
• Fluorescent Dyes
• Head and Neck Neoplasms
• Humans
• Indocyanine Green
• Lymphatic Metastasis (diagnosis, diagnostic imaging)
• Melanoma (diagnosis, diagnostic imaging, secondary)
• Organotechnetium Compounds
• Phytic Acid
• Radionuclide Imaging
• Radiopharmaceuticals
• Rosaniline Dyes
• Sentinel Lymph Node Biopsy (methods)
• Skin Neoplasms
• Technetium
• Technetium Compounds
• Tin Compounds