Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation.

Abstract

Safety and efficacy of a biologically active derivative of vitamin B(5) (pantethine) on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) metabolism was studied in North American subjects at conventional low to moderate cardiovascular disease (CVD) risk. A total of 120 subjects initiated a therapeutic lifestyle change (TLC) diet 4 weeks before randomization (baseline) and maintained the diet throughout a 16-week study period; at baseline, subjects were randomized in a triple-blinded manner to either pantethine (600 mg/d, baseline to week 8, and 900 mg/d, weeks 9-16) or identically labeled, nonbiologically active placebo (n = 60 per group). We hypothesized that pantethine would lower TC and low-density lipoprotein in low-CVD-risk North American subjects in a similar manner as reported in high-CVD-risk subjects studied mainly in Italy and Japan. While sustaining a TLC diet and in comparison with placebo, pantethine demonstrated significant (P < .005) and sustained reductions (from baseline to week 16) in TC (6 mg/dL, 0.16 mmol/L, 3%), LDL-C (4 mg/dL, 0.10 mmol/L, 4%), and apolipoprotein B (4 mg/dL, 0.04 g/L, 5%). Our data suggest that pantethine supplementation for 16 weeks (600 mg/d for weeks 1-8 then 900 mg/d for weeks 9-16) is safe and significantly lowers TC and LDL-C over and above the effect of TLC diet alone. Although the absolute magnitude of these effects was small in these low- to moderate-risk North Americans (4-6 mg/dL), the results are noteworthy as prior studies have shown that, for each 1 mg/dL (0.026 mmol/L) reduction in LDL-C, there is a concomitant 1% reduction in overall future CVD risk.

• Authors: John A Rumberger, Joseph Napolitano, Isao Azumano, Toshikazu Kamiya, Malkanthi Evans
• Journal: Nutrition research (New York, N.Y.) (Nutr Res) Vol. 31 Issue 8 Pg. 608-15 (Aug 2011) ISSN: 1879-0739 [Electronic] United States
• PMID: 21925346 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Apolipoproteins B
• Cholesterol, LDL
• Vitamin B Complex
• Pantetheine
• pantethine
• Cholesterol

Topics

• Adult
• Apolipoproteins B (blood)
• Cardiovascular Diseases (blood, prevention & control)
• Cholesterol (blood)
• Cholesterol, LDL (blood)
• Diet
• Dietary Supplements
• Double-Blind Method
• Female
• Health Promotion
• Humans
• Life Style
• Male
• Middle Aged
• North America
• Pantetheine (analogs & derivatives, pharmacology, therapeutic use)
• Risk
• Vitamin B Complex (pharmacology, therapeutic use)