Adoptive immunotherapy with virus-specific T cells.

Abstract

Viral infections are still common causes of morbidity and mortality in immunosuppressed patients after allogeneic hematopoietic stem cell transplantation. Infections caused by virus such as cytomegalovirus, adenovirus and Epstein-Barr virus are well-known. In addition, several other viruses such as polyomavirus and human herpesvirus 6 have been recently reported to be causes of significant complications. As the delay in recovery of virus-specific cellular immune response after transplant is associated with viral reactivation and viral disease, adoptive immunotherapy to restore virus-specific cellular immunity is an attractive option. Recent clinical trials showed the safety and effectiveness of adoptive immunotherapy against viral diseases. In this review, we summarize the current status of adoptive immunotherapy against several viral diseases including cytomegalovirus, adenovirus, Epstein-Barr virus and polyomavirus.

• Authors: Shigeo Fuji, Markus Kapp, Götz Ulrich Grigoleit, Hermann Einsele
• Journal: Best practice & research. Clinical haematology (Best Pract Res Clin Haematol) Vol. 24 Issue 3 Pg. 413-9 (Sep 2011) ISSN: 1532-1924 [Electronic] Netherlands
• PMID: 21925094 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Topics

• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Immunity, Cellular (immunology)
• Immunocompromised Host (immunology)
• Immunotherapy, Adoptive (methods)
• Male
• T-Lymphocytes (immunology, transplantation)
• Transplantation, Homologous
• Virus Diseases (immunology, therapy, virology)