A comparison between the effectiveness of erythromycin, single-dose clarithromycin and topical fusidic acid in the treatment of erythrasma.

Abstract

UNLABELLED:

Although erythrasma is a superficial skin infection, there is no consensus on the treatment model of erythrasma.

OBJECTIVE:

To compare the efficacy of erythromycin, single-dose clarithromycin and topical fusidic acid in the treatment of erythrasma in a double-blind, placebo-controlled, randomized trial.

METHODS:

Hundred and fifty-one patients over 18 years of age were included in this study. Patients were randomized and divided into five groups. They received clarithromycin, erythromycin, fusidic acid cream, placebo cream or placebo tablets. Patients were evaluated by Wood's light reflection scores and the initial score values and the values on the days of 2, 7 and 14 were compared statistically.

RESULTS:

According to the mean of Wood's light reflection scores, the efficacy of fusidic acid cream therapy was significantly higher than other therapies. When the efficacy of clarithromycin and erythromycin therapy was compared, clarithromycin therapy was significantly more effective than erythromycin therapy at 48 h. However, there was no statistical difference on the days of 7 and 14.

CONCLUSION:

Topical fusidic acid proved to be the most effective treatment; however, clarithromycin therapy may be an alternative regimen in the treatment of erythrasma because of its efficiency and better patient's compliance.

• Authors: Oktay Avci, Taner Tanyildizi, Ergun Kusku
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 24 Issue 1 Pg. 70-4 (Feb 2013) ISSN: 1471-1753 [Electronic] England
• PMID: 21923567 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Fusidic Acid
• Erythromycin
• Clarithromycin

Topics

• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents (therapeutic use)
• Clarithromycin (therapeutic use)
• Double-Blind Method
• Erythrasma (drug therapy)
• Erythromycin (therapeutic use)
• Female
• Fusidic Acid (therapeutic use)
• Humans
• Male
• Middle Aged
• Skin Cream
• Skin Diseases, Bacterial (drug therapy)
• Treatment Outcome
• Young Adult