Abstract |
Cepharanthin, a kind of alkaloid, has been reported to show a protective effect for leukopenia induced by radiation therapy. In this study, one of three kinds of drugs, Cepharanthin, S-Adchnon ( adrenochrome derivative) and Hythiol ( L-cysteine), was randomly administered to 94 patients with cancer of the head and neck, the uterine cervix and the lung, during the course of radiotherapy. When Cepharanthin was given, 81.3% of the patients were protected from leukopenia, compared with 51.6% in S-Adchnon and 32.3% in Hythiol. It is suggested that prophylactic use of Cepharanthin may be useful for cancer radiotherapy.
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Authors | T Ohta, K Morita |
Journal | Rinsho hoshasen. Clinical radiography
(Rinsho Hoshasen)
Vol. 35
Issue 4
Pg. 471-4
(Apr 1990)
ISSN: 0009-9252 [Print] Japan |
PMID | 2192184
(Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Alkaloids
- Benzylisoquinolines
- Radiation-Protective Agents
- S-Adchnon
- Adrenochrome
- cepharanthine
- Cysteine
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Topics |
- Adrenochrome
(analogs & derivatives, therapeutic use)
- Alkaloids
(therapeutic use)
- Benzylisoquinolines
- Cysteine
(therapeutic use)
- Female
- Humans
- Leukopenia
(drug therapy, etiology)
- Neoplasms
(radiotherapy)
- Radiation-Protective Agents
(therapeutic use)
- Radiotherapy
(adverse effects)
- Randomized Controlled Trials as Topic
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