The subject was an 85-year-old woman, who had been diagnosed as having an
ovarian cancer and carcinomatous
peritonitis and had been treated conservatively. She subsequently died from respiratory and
renal insufficiency, and the autopsy that followed revealed that her pelvic cavity had been filled by a tumorous mass that size of a child's head. Histologically, the
tumor was a
serous cystadenocarcinoma of the ovary. Moreover another
tumor, also the approximate size of a child's head, was found sited extramurally, beneath the posterior wall mucosa of the stomach body. Histological inspection of this
tumor revealed a proliferation of round oval, and spindle-shaped
tumor cells. A vacuolation of the cytoplasms and karyomitosis to the extent of 10/50 HPF also were observed. Based on the findings of being positive for
Vimentin and a negative EMA, this
tumor was diagnosed as being a malignant
leiomyoblastoma of the stomach smooth muscle. The leioblastoma is a relatively uncommon
neoplasm, and recent advances in immunohistochemical staining have indicated that some of these
tumors are not only of smooth muscle derivation but also of nerve origin. Therefore, this
tumor, given its morphological characteristics, had been generalized in this case as a gastric stromal
tumor, and with negative findings for
Desmin and
S-100 protein, as well as positive for
Vimentin.