Null genotype of glutathione S-transferase Tl contributes to colorectal cancer risk in the Asian population: a meta-analysis.

Abstract

BACKGROUND AND AIM:

Previous studies investigating the association between the glutathione S-transferase Tl (GSTT1) null genotype and colorectal cancer (CRC) risk in the Asian population have reported controversial results. Thus, a meta-analysis was performed to clarify the effect of the GSTT1 null genotype on CRC risk in the Asian population.

METHODS:

A comprehensive study was conducted, and 12 case-control studies were finally included, involving a total of 4517 CRC cases and 6607 controls. Subgroup analyses were performed by the sample size.

RESULTS:

A meta-analysis of all 12 studies showed that the GSTT1 null genotype was significantly associated with an increased CRC risk in the Asian population (odds ratio [OR] = 1.10, 95% confidence interval [CI] = 1.02-1.19, the P-value of the OR [P(OR)] = 0.02, the value of the heterogeneity analysis [I(2)] = 42%). A more obvious association was observed after the heterogeneity was eliminated by excluding one study (OR = 1.15, 95% CI: 1.06-1.25, P(OR) = 0.001, I(2) = 0%). This association was further identified by both subgroup analyses and a sensitivity analysis.

CONCLUSIONS:

This meta-analysis suggests that the GSTT1 null genotype contributes to an increased colorectal cancer risk in the Asian population.

• Authors: Shan Zhong, Jia-He Yang, Kai Liu, Bing-Hua Jiao, Zhijie Chang
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 27 Issue 2 Pg. 231-7 (Feb 2012) ISSN: 1440-1746 [Electronic] Australia
• PMID: 21916987 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.

Chemical References

• glutathione S-transferase T1
• Glutathione Transferase

Topics

• Asia (epidemiology)
• Asian People (genetics)
• Case-Control Studies
• Chi-Square Distribution
• Colorectal Neoplasms (enzymology, ethnology, genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Glutathione Transferase (genetics)
• Humans
• Male
• Middle Aged
• Odds Ratio
• Phenotype
• Risk Assessment
• Risk Factors