Abstract | BACKGROUND: METHODS: Fifty patients with cardiovascular diseases [61 ± 13 (mean ± SD) years old, male/female 44/6] participated. Each subject performed CR using aerobic bicycle exercise two or three times per week for 3-6 months. We measured resting serum high-sensitivity CRP ( hsCRP), SAA, and plasma PTX3 before and 3 and 6 months after CR, and compared them with VO(2peak) determined using a standard increment cycle ergometer protocol, B-type natriuretic peptide (BNP), and other biochemical data such as HbA1c. RESULTS: There was a significant positive correlation between hsCRP and SAA (r = 0.92, p < 0.001), but no relations between these parameters and PTX3. Plasma PTX3 significantly decreased time dependently during CR (at baseline 3.2 ± 2.0 ng/ml, at 3 months 2.3 ± 0.8 ng/ml, at 6 months 2.1 ± 0.7 ng/ml; all p < 0.05). Serum hsCRP tended to decrease, but not statistically significantly. At baseline, plasma PTX3 was negatively correlated with the percentage of the predicted values of VO(2peak) and positively correlated with BNP. CR significantly increased the percentage of the predicted values of VO(2peak) and decreased BNP. CONCLUSIONS:
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Authors | Taira Fukuda, Miwa Kurano, Haruko Iida, Haruhito Takano, Tomofumi Tanaka, Yumiko Yamamoto, Kenichi Ikeda, Mika Nagasaki, Koshiro Monzen, Kansei Uno, Masayoshi Kato, Taro Shiga, Koji Maemura, Nobuhito Masuda, Hiroshi Yamashita, Yasunobu Hirata, Ryozo Nagai, Toshiaki Nakajima |
Journal | European journal of preventive cardiology
(Eur J Prev Cardiol)
Vol. 19
Issue 6
Pg. 1393-400
(Dec 2012)
ISSN: 2047-4881 [Electronic] England |
PMID | 21914683
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Glycated Hemoglobin A
- Inflammation Mediators
- Serum Amyloid A Protein
- Serum Amyloid P-Component
- hemoglobin A1c protein, human
- Natriuretic Peptide, Brain
- PTX3 protein
- C-Reactive Protein
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Topics |
- Aged
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Cardiac Rehabilitation
- Cardiovascular Diseases
(blood, diagnosis, physiopathology)
- Chi-Square Distribution
- Down-Regulation
- Exercise Test
- Exercise Therapy
- Exercise Tolerance
- Female
- Glycated Hemoglobin
(metabolism)
- Humans
- Inflammation Mediators
(blood)
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Oxygen Consumption
- Recovery of Function
- Serum Amyloid A Protein
(metabolism)
- Serum Amyloid P-Component
(metabolism)
- Time Factors
- Treatment Outcome
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