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Ethanol injection is highly effective for hepatocellular carcinoma smaller than 2 cm.

AbstractAIM:
To analyze the long-term prognosis in a cohort of western cirrhotic patients with single hepatocellular carcinoma treated with ethanol injection.
METHODS:
One-hundred forty-eight patients with solitary hepatocellular carcinoma were enrolled. The tumor diameter was lower than 2 cm in 47 patients but larger in the remaining 101 patients. The impact of some pre-treatment clinical and laboratory parameters and of tumor recurrence on patients' survival was assessed.
RESULTS:
Among the pre-treatment parameters, only a tumor diameter of less than 2 cm was an independent prognostic factor of survival. The occurrence of new nodules in other liver segments and the neoplastic portal invasion were linked to a poorer prognosis at univariate analysis. Patients with a single hepatocellular carcinoma smaller than 2 cm showed a better 5-year cumulative survival (73.0% vs 47.9%) (P = 0.009), 3-year local recurrence rate (29.1% vs 51.5%) (P = 0.011), and 5-year distant intrahepatic recurrence rate (52.9% vs 62.8%) (P = 0.054) compared to patients with a larger tumor.
CONCLUSION:
The 5-year survival rate of patients with single hepatocellular carcinoma < 2 cm undergoing ethanol injection is excellent and comparable to that achieved using radiofrequency ablation.
AuthorsMaurizio Pompili, Erica Nicolardi, Valeria Abbate, Luca Miele, Laura Riccardi, Marcello Covino, Nicoletta De Matthaeis, Antonio Grieco, Raffaele Landolfi, Gian Ludovico Rapaccini
JournalWorld journal of gastroenterology (World J Gastroenterol) Vol. 17 Issue 26 Pg. 3126-32 (Jul 14 2011) ISSN: 2219-2840 [Electronic] United States
PMID21912455 (Publication Type: Journal Article)
Chemical References
  • Ethanol
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular (diagnosis, drug therapy, pathology)
  • Cohort Studies
  • Disease-Free Survival
  • Ethanol (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Injections
  • Liver Neoplasms (diagnosis, drug therapy, pathology)
  • Male
  • Middle Aged
  • Survival Rate
  • Treatment Outcome

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