Abstract | AIM: METHODS: One-hundred forty-eight patients with solitary hepatocellular carcinoma were enrolled. The tumor diameter was lower than 2 cm in 47 patients but larger in the remaining 101 patients. The impact of some pre-treatment clinical and laboratory parameters and of tumor recurrence on patients' survival was assessed. RESULTS: Among the pre-treatment parameters, only a tumor diameter of less than 2 cm was an independent prognostic factor of survival. The occurrence of new nodules in other liver segments and the neoplastic portal invasion were linked to a poorer prognosis at univariate analysis. Patients with a single hepatocellular carcinoma smaller than 2 cm showed a better 5-year cumulative survival (73.0% vs 47.9%) (P = 0.009), 3-year local recurrence rate (29.1% vs 51.5%) (P = 0.011), and 5-year distant intrahepatic recurrence rate (52.9% vs 62.8%) (P = 0.054) compared to patients with a larger tumor. CONCLUSION:
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Authors | Maurizio Pompili, Erica Nicolardi, Valeria Abbate, Luca Miele, Laura Riccardi, Marcello Covino, Nicoletta De Matthaeis, Antonio Grieco, Raffaele Landolfi, Gian Ludovico Rapaccini |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 17
Issue 26
Pg. 3126-32
(Jul 14 2011)
ISSN: 2219-2840 [Electronic] United States |
PMID | 21912455
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Hepatocellular
(diagnosis, drug therapy, pathology)
- Cohort Studies
- Disease-Free Survival
- Ethanol
(administration & dosage, therapeutic use)
- Female
- Humans
- Injections
- Liver Neoplasms
(diagnosis, drug therapy, pathology)
- Male
- Middle Aged
- Survival Rate
- Treatment Outcome
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