[Prophylaxis of thromboembolic events in surgery. DVT prophylaxis: a comparison of out-patient and hospitalized patients].

Abstract

BACKGROUND:

The aim of this study was to compare the efficacy and tolerability of enoxaparin for preventing thromboembolism after surgery in the out-patient and in-hospital settings.

MATERIALS AND METHODS:

A total of 2,005 out-patient and 1,360 hospitalized patients were included in the study. Prophylaxis was carried out with 20 or 40 mg enoxaparin and follow-up examination after 4-6 weeks.

RESULTS:

Out-patients were younger (mean 48.4 vs. 58.5 years, p<0.01), had less cardiovascular comorbid diseases (7.1 vs. 20.8%, p<0.01) and underwent less complex interventions (arthroscopy 33.6 vs. 7.5%, p<0.01). Out-patients also received 20 instead of 40 mg enoxaparin more frequently (60.7 vs. 38.3%, p<0.01). The mean duration of thromboprophylaxis was reduced (12.6 vs. 15.3 days). For patients treated with 20 and 40 mg minor bleeding was observed in 1.8 and 3.4%, respectively (4.7 with 20 mg and 4.5% with 40 mg in hospital), major bleeding was 0.1% for both doses in out-patients and 0.0% with 20 mg and 0.3% with 40 mg in-hospital. Deep vein thrombosis (DVT) occurred in 0.4% of out-patients receiving 20 mg enoxaparin and 0.6% with 40 mg (0.0% with 20 mg and 0.9% with 40 mg in-hospital). There were no cases of pulmonary embolism (PE) in out-patients but PE was observed in 0.2% and 0.5% with 20 mg and 40 mg in-hospital patients, respectively.

CONCLUSIONS:

Thromboprophylaxis with enoxaparin is well tolerated under clinical conditions as well as under out-patient treatment and severe bleeding complications are rare.

• Authors: K Fecher, W Ewald, A Fürst, V Hohmann, P Bramlage
• Journal: Der Unfallchirurg (Unfallchirurg) Vol. 116 Issue 3 Pg. 246-54 (Mar 2013) ISSN: 1433-044X [Electronic] Germany
• Vernacular Title: Prophylaxe thromboembolischer Ereignisse in der Chirurgie. TVT-Prophylaxe: Vergleich ambulant vs. stationär.
• PMID: 21909736 (Publication Type: Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Enoxaparin
• Fibrinolytic Agents

Topics

• Ambulatory Care (statistics & numerical data)
• Comorbidity
• Enoxaparin (therapeutic use)
• Female
• Fibrinolytic Agents (therapeutic use)
• Germany (epidemiology)
• Hospitalization (statistics & numerical data)
• Humans
• Inpatients (statistics & numerical data)
• Male
• Middle Aged
• Outpatients (statistics & numerical data)
• Postoperative Complications (epidemiology, prevention & control)
• Prevalence
• Risk Assessment
• Treatment Outcome
• Venous Thrombosis (prevention & control)