Pyroglutamic acid improves the age associated memory impairment.

Abstract

Pyroglutamic acid (PCA) was compared with placebo in a randomized, double blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with PCA and 20 with placebo over a period of 60 d. Memory functions were evaluated at baseline and after 60 d of treatment by means of a battery made up of 6 memory tasks. The results suggest that PCA is effective in improving some verbal memory functions in subjects affected by age-related memory decline.

• Authors: S Grioli, C Lomeo, M C Quattropani, G Spignoli, C Villardita
• Journal: Fundamental & clinical pharmacology (Fundam Clin Pharmacol) Vol. 4 Issue 2 Pg. 169-73 ( 1990) ISSN: 0767-3981 [Print] England
• PMID: 2190900 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Pyrrolidinones
• Pyrrolidonecarboxylic Acid

Topics

• Aged
• Aged, 80 and over
• Double-Blind Method
• Form Perception (drug effects)
• Humans
• Memory Disorders (drug therapy, psychology)
• Middle Aged
• Psychomotor Performance (drug effects)
• Pyrrolidinones (therapeutic use)
• Pyrrolidonecarboxylic Acid (therapeutic use)
• Randomized Controlled Trials as Topic