Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery.

Abstract

PURPOSE:

To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX).

METHODS:

LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model.

RESULTS:

Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40°C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX.

CONCLUSIONS:

The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.

• Authors: Jang Kyoung Kim, Young-Wook Won, Kwang Suk Lim, Yong-Hee Kim
• Journal: Pharmaceutical research (Pharm Res) Vol. 29 Issue 2 Pg. 525-34 (Feb 2012) ISSN: 1573-904X [Electronic] United States
• PMID: 21904934 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Delayed-Action Preparations
• Micelles
• Taxoids
• Poloxamer
• Docetaxel
• Methylcellulose

Topics

• Animals
• Antineoplastic Agents (administration & dosage, pharmacokinetics, therapeutic use)
• Delayed-Action Preparations (chemistry)
• Docetaxel
• Male
• Methylcellulose (chemistry)
• Mice
• Mice, Inbred C57BL
• Micelles
• Neoplasms (drug therapy)
• Poloxamer (chemistry)
• Taxoids (administration & dosage, pharmacokinetics, therapeutic use)