Motor improvement with bilateral subthalamic nucleus deep brain stimulation in a patient with levodopa-responsive secondary parkinsonism.

Abstract

At many centers, subthalamic nucleus (STN) deep brain stimulation (DBS) is not considered for patients with secondary forms of parkinsonism, due to higher expected rates of treatment failure. We present the case of a woman with secondary parkinsonism that developed following a Measles, Mumps, and Rubella (MMR) vaccination, who experienced sustained improvement in motor function following STN DBS. Despite the diagnosis of a secondary parkinsonism, this patient responded well to dopaminergic therapy, a good predictor of DBS outcome in patients with idiopathic Parkinson's disease. This case suggests that DBS may be considered in the setting of secondary parkinsonism if such patients have levodopa-responsive symptoms.

• Authors: Vikas Kotagal, Parag G Patil, Kelvin L Chou
• Journal: Parkinsonism & related disorders (Parkinsonism Relat Disord) Vol. 18 Issue 1 Pg. 79-81 (Jan 2012) ISSN: 1873-5126 [Electronic] England
• PMID: 21903443 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Measles-Mumps-Rubella Vaccine
• Levodopa

Topics

• Deep Brain Stimulation (methods)
• Female
• Humans
• Levodopa (therapeutic use)
• Measles-Mumps-Rubella Vaccine (adverse effects)
• Middle Aged
• Motor Skills (physiology)
• Parkinson Disease, Secondary (chemically induced, physiopathology, therapy)
• Subthalamic Nucleus (physiology)
• Treatment Outcome