Abstract | BACKGROUND: METHODS: RESULTS: Preoperative hypercalciuria was present in ∼65% in both groups (P = .68). Parathyroidectomy decreased serum levels of calcium, parathyroid hormone, and urinary calcium, but there were no differences between stone formers and nonstone formers. Stone formers were 12-fold (P = .001) more likely to resolve an increase in supersaturation of calcium oxalate (SSCaOx), and after adjustment for age, sex, and BMI were 46-fold (P = .002) more likely to resolve an increase in SSCaOx. After parathyroidectomy, the rate of stone recurrence was 23% and male sex (aOR 20, P = .032) and increasing BMI (aOR 1.23, P = .038) were the only independent predictors of stone recurrence after adjusting for age. No other factor evaluated preoperatively, postoperatively, or the change after parathyroidectomy differentiated stone and nonstone formers or predicted stone recurrence. CONCLUSION: Metabolic evaluation did not differentiate stone formers from nonstone formers reliably. Stone formers were more likely to resolve an increase in SSCaOx after parathyroidectomy. Male sex and increasing BMI were independently associated with stone recurrence after parathyroidectomy.
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Authors | Mathew D Sorensen, Quan-Yang Duh, Raymon H Grogan, Thanh C Tran, Marshall L Stoller |
Journal | Surgery
(Surgery)
Vol. 151
Issue 3
Pg. 477-83
(Mar 2012)
ISSN: 1532-7361 [Electronic] United States |
PMID | 21893327
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Mosby, Inc. All rights reserved. |
Chemical References |
- Parathyroid Hormone
- Calcium Oxalate
- Calcium
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Topics |
- Adult
- Aged
- Calcium
(urine)
- Calcium Oxalate
(urine)
- Female
- Humans
- Hypercalciuria
(etiology, urine)
- Hyperparathyroidism, Primary
(complications, surgery, urine)
- Male
- Middle Aged
- Nephrolithiasis
(etiology, urine)
- Parathyroid Hormone
(urine)
- Parathyroidectomy
- Recurrence
- Risk Factors
- Young Adult
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