High-dose oral fluconazole therapy effective for cutaneous leishmaniasis due to Leishmania (Vianna) braziliensis.

We report for the first time the successful use of fluconazole to treat cutaneous leishmaniasis due to Leishmania braziliensis. We used escalating doses from 5 to 8 mg/kg per day. At a dose of 5 mg/kg per day, 75% patients were cured, and at 8 mg/kg per day, the cure rate was 100%. Fluconazole was well tolerated.
AuthorsAnastácio Q Sousa, Mércia S Frutuoso, Elisabete A Moraes, Richard D Pearson, Margarida M L Pompeu
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 53 Issue 7 Pg. 693-5 (Oct 2011) ISSN: 1537-6591 [Electronic] United States
PMID21890773 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Antiprotozoal Agents
  • Fluconazole
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antiprotozoal Agents (administration & dosage, adverse effects)
  • Child
  • Child, Preschool
  • Female
  • Fluconazole (administration & dosage, adverse effects)
  • Humans
  • Leishmania braziliensis (drug effects, isolation & purification)
  • Leishmaniasis, Cutaneous (drug therapy, parasitology)
  • Male
  • Middle Aged
  • Treatment Outcome
  • Young Adult

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