Abstract |
We report for the first time the successful use of fluconazole to treat cutaneous leishmaniasis due to Leishmania braziliensis. We used escalating doses from 5 to 8 mg/kg per day. At a dose of 5 mg/kg per day, 75% patients were cured, and at 8 mg/kg per day, the cure rate was 100%. Fluconazole was well tolerated.
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Authors | Anastácio Q Sousa, Mércia S Frutuoso, Elisabete A Moraes, Richard D Pearson, Margarida M L Pompeu |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 53
Issue 7
Pg. 693-5
(Oct 2011)
ISSN: 1537-6591 [Electronic] United States |
PMID | 21890773
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antiprotozoal Agents
- Fluconazole
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antiprotozoal Agents
(administration & dosage, adverse effects)
- Child
- Child, Preschool
- Female
- Fluconazole
(administration & dosage, adverse effects)
- Humans
- Leishmania braziliensis
(drug effects, isolation & purification)
- Leishmaniasis, Cutaneous
(drug therapy, parasitology)
- Male
- Middle Aged
- Treatment Outcome
- Young Adult
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