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Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry.

Abstract
The purpose of the current study was to assess the effects of long-term exposure to low levels of DDVP on the biochemical parameters and metabolic profiles of rats. Three different doses (2.4, 7.2, and 21.6 mg/kg body weight/day) of DDVP were administered to rats through their drinking water over 24 weeks. Significant changes in blood cholinesterase, creatinine, urea nitrogen, aspartate aminotransferase, alanine aminotransferase, and albumin concentrations were observed in the middle and high dose groups. Changes in the concentration of some urine metabolites were detected via ultra performance liquid chromatography-mass spectrometry (UPLC-MS). Dimethyl phosphate (DMP), which was exclusively detected in the treated groups, can be an early, sensitive biomarker for DDVP exposure. Moreover, DDVP treatment resulted in an increase in the lactobionic acid, estrone sulfate, and indoxyl sulfic concentrations, and a decrease in citric acid, suberic acid, gulonic acid, urea, creatinine, and uric acid. These results suggest that chronic exposure to low-level DDVP can cause a disturbance in carbohydrate and fatty acid metabolism, the antioxidant system, etc. Therefore, an analysis of the metabolic profiles can contribute to the understanding of the adverse effects of long-term exposure to low doses of DDVP.
AuthorsJindan Yang, Xiaowei Sun, Zhijing Feng, Dongfang Hao, Maoqing Wang, Xiujuan Zhao, Changhao Sun
JournalToxicology letters (Toxicol Lett) Vol. 206 Issue 3 Pg. 306-13 (Oct 30 2011) ISSN: 1879-3169 [Electronic] Netherlands
PMID21889581 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Biomarkers
  • Cholinesterase Inhibitors
  • Insecticides
  • Dichlorvos
Topics
  • Animals
  • Biomarkers
  • Cholinesterase Inhibitors (toxicity)
  • Chromatography, Liquid
  • Dichlorvos (toxicity)
  • Dose-Response Relationship, Drug
  • Insecticides (toxicity)
  • Kidney (drug effects)
  • Male
  • Mass Spectrometry
  • Metabolomics
  • Principal Component Analysis
  • Rats
  • Rats, Wistar
  • Weight Gain (drug effects)

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