Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in a Taiwan Chinese Han population.

Abstract

OBJECTIVE:

Lumican (LUM) is predominantly localized in areas of pathological fibrosis. To determine whether polymorphisms in LUM gene are associated with development of systemic lupus erythematosus (SLE), we analyzed 2 single-nucleotide polymorphisms (SNP) of LUM in a Taiwan Chinese Han population.

METHODS:

Participants included 168 patients with SLE and 192 age-matched controls in whom examinations had excluded SLE. Genotyping of -628 A/-(rs17018757) and c.1567 T/C polymorphisms in LUM were carried out in each patient and control using the polymerase chain reaction-restriction fragment-length polymorphism method, and validated by Taqman SNP genotyping assay. Data were correlated with the development of SLE and various clinical symptoms by chi-square analysis.

RESULTS:

Frequencies of C/C genotype and the C allele at c.1567 T/C were significantly higher in patients than controls. Polymorphism at c.1567 C/T was found to be associated with arthritis and photosensitivity in patients with SLE, which are both connective tissue-related symptoms.

CONCLUSION:

The c.1567 T/C polymorphism of LUM is related to the development and clinical symptoms of SLE.

• Authors: Pei-Chun Chang, Yi Chen, Ming-Tsong Lai, Heng-Yuan Chang, Chung-Ming Huang, Hsin-Ping Liu, Wei-Yong Lin, Chih-Ho Lai, Jim Jinn-Chyuan Sheu, Fuu-Jen Tsai
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 38 Issue 11 Pg. 2376-81 (Nov 2011) ISSN: 0315-162X [Print] Canada
• PMID: 21885486 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chondroitin Sulfate Proteoglycans
• LUM protein, human
• Lumican
• Keratan Sulfate

Topics

• Asian People (genetics)
• Case-Control Studies
• Chondroitin Sulfate Proteoglycans (genetics)
• Gene Frequency (genetics)
• Genetic Linkage (genetics)
• Genetic Predisposition to Disease (ethnology, genetics)
• Genotype
• Humans
• Keratan Sulfate (genetics)
• Lumican
• Lupus Erythematosus, Systemic (ethnology, genetics)
• Polymorphism, Single Nucleotide (genetics)
• Taiwan