Abstract | INTRODUCTION:
Priapism is a common concern in sickle cell disease. With a high frequency of recurrences and serious long-term sequela, a preventative, rather than traditionally reactive approach, needs to be taken in these patients. Reports have shown successful use of sildenafil as a prophylactic treatment but have failed to address adverse outcomes, including vasoocclusive pain crises, of chronic sildenafil therapy in sickle cell patients. AIMS: We wish to draw attention to the potential adverse outcomes of this therapy on the overall state of the patient's disease for consideration in future studies. METHODS: RESULTS:
Sildenafil was successful in decreasing the frequency of priapism; however, our patient experienced an increased frequency of vasoocclusive crises, something not previously addressed. CONCLUSION:
|
Authors | Andrew Lane, Ruby Deveras |
Journal | The journal of sexual medicine
(J Sex Med)
Vol. 8
Issue 11
Pg. 3193-5
(Nov 2011)
ISSN: 1743-6109 [Electronic] Netherlands |
PMID | 21883942
(Publication Type: Case Reports, Journal Article)
|
Copyright | © 2011 International Society for Sexual Medicine. |
Chemical References |
- Phosphodiesterase 5 Inhibitors
- Piperazines
- Purines
- Sulfones
- Sildenafil Citrate
|
Topics |
- Adult
- Anemia, Sickle Cell
(complications)
- Humans
- Male
- Penile Erection
(drug effects)
- Phosphodiesterase 5 Inhibitors
(administration & dosage, adverse effects, therapeutic use)
- Piperazines
(administration & dosage, adverse effects, therapeutic use)
- Priapism
(drug therapy, etiology)
- Purines
(administration & dosage, adverse effects, therapeutic use)
- Sildenafil Citrate
- Sulfones
(administration & dosage, adverse effects, therapeutic use)
|