The efficacy of a topical gel with triester glycerol oxide in denture-related mucosal injuries.

Abstract

OBJECTIVE:

The efficacy of a topical gel with triester glycerol oxide for treating ulcerations related to new complete dentures was studied and compared with a placebo gel.

MATERIALS AND METHODS:

Fifty edentulous patients were enrolled in this double-blind clinical study. All subjects received new maxillary and mandibular complete dentures and were recalled 1, 3 and 7 days after denture placement. Twenty-five subjects received topical gel with triester glycerol oxide (TGO), and 25 subjects received topical gel without TGO. At each visit, pain and discomfort with the new dentures was assessed, and at the last visit, healing of ulcerations was also graded by a clinician. Subjects also graded the gel's taste, smell and ease of use.

RESULTS:

Specifically, there was no statistically significant difference in ulcer healing (p > 0.05), ratings of smell, taste and ease of use (p > 0.05) or pain and discomfort scores (p > 0.05). However, within-group differences were observed in pain and discomfort scores between follow-up sessions (p = 0.01 for all comparisons).

CONCLUSION:

Clinically, TGO gel is not effective in the treatment of mucosal injuries occurring following placement of complete dentures.

• Authors: Onur Geckili, Kivanc Bektas-Kayhan, Pinar Eren, Tayfun Bilgin, Meral Unur
• Journal: Gerodontology (Gerodontology) Vol. 29 Issue 2 Pg. e715-20 (Jun 2012) ISSN: 1741-2358 [Electronic] England
• PMID: 21883424 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: © 2011 The Gerodontology Society and John Wiley & Sons A/S.

Chemical References

• Emollients
• Gels
• Placebos
• Triglycerides
• Glycerol

Topics

• Administration, Topical
• Aged
• Aged, 80 and over
• Denture, Complete (adverse effects)
• Double-Blind Method
• Emollients (therapeutic use)
• Follow-Up Studies
• Gels
• Glycerol (therapeutic use)
• Humans
• Middle Aged
• Mouth Mucosa (drug effects, injuries)
• Mouth, Edentulous (rehabilitation)
• Oral Hygiene
• Oral Ulcer (drug therapy, etiology)
• Pain (prevention & control)
• Patient Satisfaction
• Placebos
• Smell (drug effects)
• Smoking
• Stomatitis, Denture (drug therapy, etiology)
• Taste (drug effects)
• Tissue Conditioning, Dental
• Treatment Outcome
• Triglycerides (therapeutic use)