Abstract | BACKGROUND: METHODS: From January 1995 to September 1999, tissue samples from 153 patients with ESCC who underwent esophagectomies at our institutions were collected and made into tissue core arrays for study. Expression of NBS1 and Snail was examined by immunohistochemical staining. The clinicopathologic data were analyzed, and some additional studies were performed to explore the relationship between NBS1 and Snail. RESULTS: NBS1 overexpression was observed in 28.1% (43/153) of ESCC, whereas Snail overexpression was observed in 26.1% (40/153) of ESCC. Overexpression of NBS1 correlated inversely with nodal status (P = 0.009) and was associated with better overall survival (P = 0.002). On the other hand, overexpression of Snail correlated positively with lymphovascular invasion (P = 0.034) and was associated with worse overall survival (P = 0.036). Meanwhile, NBS1 overexpression correlated inversely with Snail overexpression marginally (P = 0.084). Using the Cox regression analysis, T status (P = 0.006), M status (P = 0.008), and NBS1 overexpression (P = 0.007) were the independent factors of overall survival. CONCLUSIONS: Our results showed that NBS1 overexpression was an independent factor of better survival and Snail overexpression predicted a worse survival in ESCC. Combination of NBS1 plus Snail expression status could be used as a predictor of prognosis in ESCC.
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Authors | Kuang-Tai Kuo, Teh-Ying Chou, Han-Shui Hsu, Wen-Liang Chen, Liang-Shun Wang |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 19 Suppl 3
Pg. S549-57
(Jul 2012)
ISSN: 1534-4681 [Electronic] United States |
PMID | 21881923
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Cadherins
- Cell Cycle Proteins
- NBN protein, human
- Nuclear Proteins
- Snail Family Transcription Factors
- Transcription Factors
- Proto-Oncogene Proteins c-akt
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Cadherins
(metabolism)
- Carcinoma, Squamous Cell
(metabolism, secondary)
- Cell Cycle Proteins
(metabolism)
- Esophageal Neoplasms
(metabolism, pathology)
- Female
- Humans
- Kaplan-Meier Estimate
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Staging
- Nuclear Proteins
(metabolism)
- Proportional Hazards Models
- Proto-Oncogene Proteins c-akt
(metabolism)
- Retrospective Studies
- Snail Family Transcription Factors
- Transcription Factors
(metabolism)
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