Abstract | BACKGROUND: Functional imaging provides a valuable adjunct to clinical evaluation for assessing the efficacy of cell-based restorative therapies in Parkinson's disease (PD). SOURCES OF DATA: In this article, we review the latest advances on the use of positron emission tomography (PET) imaging in evaluating the surgical outcome of embryonic dopamine (DA) cell transplantation in PD patients. AREAS OF AGREEMENT: AREAS OF CONTROVERSY: Adverse events subsequent to transplantation have also been noted and attributed to a variety of causes. GROWING POINTS: AREAS TIMELY FOR DEVELOPING RESEARCH: Given continued progress in DA neuron production from stem cells in recent years, transplantation of neural stem cells may be the next to enter clinical trials in patients. CONCLUSION:
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Authors | Yilong Ma, Shichun Peng, Vijay Dhawan, David Eidelberg |
Journal | British medical bulletin
(Br Med Bull)
Vol. 100
Pg. 173-89
( 2011)
ISSN: 1471-8391 [Electronic] England |
PMID | 21875864
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Topics |
- Brain
(diagnostic imaging)
- Embryonic Stem Cells
(transplantation)
- Humans
- Parkinson Disease
(diagnostic imaging, therapy)
- Positron-Emission Tomography
- Stem Cell Transplantation
(adverse effects, trends)
- Substantia Nigra
(transplantation)
- Treatment Outcome
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