Chronic ulcerative stomatitis: a distinct clinical entity?

Abstract

Chronic ulcerative stomatitis (CUS) is a mucocutaneous disorder which is characterised by persistent oral mucosal ulceration. The clinical appearance is often reminiscent of oral lichen planus (OLP) leading to erroneous diagnoses. The immune mediated inhibition of the CUS protein (CUSP) is implicated in the pathogenesis of CUS. CUSP acts as an anti-apoptotic protein and when its action is prevented it may result in significant epithelial injury. The objective or this article is to present the first documented case of CUS in South Africa, with relevant reference to current international literature. CUS should be considered in patients previously diagnosed with OLP but who are unresponsive to glucocorticosteroid therapy. The condition can be successfully managed using hydroxychloroquine.

• Authors: J Fourie, W F P van Heerden, S C McEachen, A van Zyl
• Journal: SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging (SADJ) Vol. 66 Issue 3 Pg. 119-21 (Apr 2011) ISSN: 1029-4864 [Print] South Africa
• PMID: 21874892 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antirheumatic Agents
• Immunosuppressive Agents
• Hydroxychloroquine
• Cyclosporine

Topics

• Adult
• Antirheumatic Agents (therapeutic use)
• Chronic Disease
• Cyclosporine (therapeutic use)
• Diagnosis, Differential
• Female
• Gingivitis, Necrotizing Ulcerative (drug therapy, pathology)
• Humans
• Hydroxychloroquine (therapeutic use)
• Immunosuppressive Agents (therapeutic use)
• Lichen Planus, Oral (diagnosis)
• Mouth Mucosa (pathology)
• Skin Ulcer (drug therapy)
• South Africa