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Prognostic value of proliferating cell nuclear antigen in parotid gland cancer.

Abstract
Although cell proliferation is related to tumour aggressiveness and prognosis, there are few studies describing the expression of proliferative markers in salivary gland cancer. Our aim was to assess the long-term prognostic value of the proliferating cell nuclear antigen (PCNA) in a large group of histologically different salivary gland cancers. We analysed the expression of PCNA in 159 patients with parotid gland cancer by means of immunohistochemistry. The mean follow-up time was 56.6 months. A high expression of PCNA showed a significant correlation to the patients' pathological lymph node stage (p = 0.004). A high PCNA expression significantly indicated a poor 5-year disease-free (p = 0.046) and overall survival rate (p = 0.018). The PCNA expression was the only prognostic factor for a worse 5-year disease-free and overall survival in acinic cell carcinomas (p = 0.004, p = 0.022). The correlation between PCNA expression and survival probabilities of salivary gland cancer might make proliferation markers helpful tools in patient follow-up, prognosis and targeted therapy in salivary gland cancer in future.
AuthorsMarkus Stenner, Ariane Demgensky, Christoph Molls, Aline Hardt, Jan C Luers, Maria Grosheva, Christian U Huebbers, Jens P Klussmann
JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 269 Issue 4 Pg. 1225-32 (Apr 2012) ISSN: 1434-4726 [Electronic] Germany
PMID21874325 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Proliferating Cell Nuclear Antigen
Topics
  • Biomarkers, Tumor (metabolism)
  • Carcinoma, Acinar Cell (metabolism, pathology)
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Parotid Gland (chemistry, pathology)
  • Parotid Neoplasms (diagnosis, metabolism, mortality)
  • Prognosis
  • Proliferating Cell Nuclear Antigen (biosynthesis)
  • Survival Rate

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