Abstract | OBJECTIVE: Excessive accumulation of visceral fat is strongly associated with insulin resistance. The present investigation examined the effects of dietary intake of medium- and long-chain triacylglycerols (MLCTs), which have been shown to induce significantly lower visceral fat accumulation in rats and humans, on high-fat diet-induced obesity and insulin resistance in rats. These effects were then compared with those observed in long-chain triacylglycerol (LCT)-fed rats. METHODS: After an 8-wk feeding of a high-fat diet, which induced severe whole-body insulin resistance, male Sprague-Dawley rats were fed a standard diet containing LCTs or MLCTs for 6 wk. After the dietary treatment, an oral glucose tolerance test was performed. RESULTS: Although body weight and total intra-abdominal fat mass did not differ between the two groups, mesenteric fat weight in the MLCT-fed group was significantly lower than that in the LCT group (P < 0.05). The increase in plasma insulin concentrations, but not in glucose, after glucose administration (area under the curve) was significantly smaller in the MLCT group than in the LCT group (P < 0.01) and was significantly associated with mesenteric fat weight (P < 0.05). MLCT-fed rats had significantly higher plasma adiponectin concentrations compared with LCT rats (P < 0.05). Adiponectin concentrations were negatively correlated with the area under the curve for plasma insulin (P < 0.05) and tended to be inversely related to mesenteric fat weight (P = 0.08). CONCLUSION: These results suggest that dietary intake of MLCTs may improve insulin resistance in rats fed a high-fat diet, at least in part through increased adiponectin concentrations caused by a lower mesenteric fat mass.
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Authors | Shin Terada, Sayuri Yamamoto, Seiji Sekine, Toshiaki Aoyama |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 28
Issue 1
Pg. 92-7
(Jan 2012)
ISSN: 1873-1244 [Electronic] United States |
PMID | 21872431
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Adiponectin
- Adipoq protein, rat
- Dietary Fats
- Fatty Acids
- Triglycerides
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Topics |
- Adiponectin
(blood)
- Adiposity
- Animals
- Body Weight
- Diet, High-Fat
(adverse effects)
- Dietary Fats
(therapeutic use)
- Fatty Acids
(analysis, chemistry)
- Insulin Resistance
- Intra-Abdominal Fat
(pathology)
- Male
- Overweight
(blood, diet therapy, metabolism, pathology)
- Rats
- Rats, Sprague-Dawley
- Triglycerides
(chemistry, therapeutic use)
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