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Dietary intake of medium- and long-chain triacylglycerols ameliorates insulin resistance in rats fed a high-fat diet.

AbstractOBJECTIVE:
Excessive accumulation of visceral fat is strongly associated with insulin resistance. The present investigation examined the effects of dietary intake of medium- and long-chain triacylglycerols (MLCTs), which have been shown to induce significantly lower visceral fat accumulation in rats and humans, on high-fat diet-induced obesity and insulin resistance in rats. These effects were then compared with those observed in long-chain triacylglycerol (LCT)-fed rats.
METHODS:
After an 8-wk feeding of a high-fat diet, which induced severe whole-body insulin resistance, male Sprague-Dawley rats were fed a standard diet containing LCTs or MLCTs for 6 wk. After the dietary treatment, an oral glucose tolerance test was performed.
RESULTS:
Although body weight and total intra-abdominal fat mass did not differ between the two groups, mesenteric fat weight in the MLCT-fed group was significantly lower than that in the LCT group (P < 0.05). The increase in plasma insulin concentrations, but not in glucose, after glucose administration (area under the curve) was significantly smaller in the MLCT group than in the LCT group (P < 0.01) and was significantly associated with mesenteric fat weight (P < 0.05). MLCT-fed rats had significantly higher plasma adiponectin concentrations compared with LCT rats (P < 0.05). Adiponectin concentrations were negatively correlated with the area under the curve for plasma insulin (P < 0.05) and tended to be inversely related to mesenteric fat weight (P = 0.08).
CONCLUSION:
These results suggest that dietary intake of MLCTs may improve insulin resistance in rats fed a high-fat diet, at least in part through increased adiponectin concentrations caused by a lower mesenteric fat mass.
AuthorsShin Terada, Sayuri Yamamoto, Seiji Sekine, Toshiaki Aoyama
JournalNutrition (Burbank, Los Angeles County, Calif.) (Nutrition) Vol. 28 Issue 1 Pg. 92-7 (Jan 2012) ISSN: 1873-1244 [Electronic] United States
PMID21872431 (Publication Type: Comparative Study, Journal Article)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.
Chemical References
  • Adiponectin
  • Adipoq protein, rat
  • Dietary Fats
  • Fatty Acids
  • Triglycerides
Topics
  • Adiponectin (blood)
  • Adiposity
  • Animals
  • Body Weight
  • Diet, High-Fat (adverse effects)
  • Dietary Fats (therapeutic use)
  • Fatty Acids (analysis, chemistry)
  • Insulin Resistance
  • Intra-Abdominal Fat (pathology)
  • Male
  • Overweight (blood, diet therapy, metabolism, pathology)
  • Rats
  • Rats, Sprague-Dawley
  • Triglycerides (chemistry, therapeutic use)

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