Abstract | BACKGROUND: METHODS: RESULTS: The RMT inhaler, combined with a new in-line adapter, was superior to other inhaler device connector or spacer combinations in FPD delivery during simulated mechanical ventilation (p<0.01). The outcome with the RMT inhaler/RMT adapter combination during simulation of mechanical ventilation was comparable to the measurements with the RMT/AeroTrachPlus valved holding chamber during simulation of spontaneous breathing. The delivery rates of the RMT adapter were not significantly affected by the administered bronchodilators or by the type of artificial airway (endotracheal or tracheostomy tube) employed. CONCLUSIONS: The RMT inhaler combined with the prototype in-line adapter was better than the other accessory device combinations in fine particle deposition of inhaled bronchodilators during mechanical ventilation. Further research is required to determine the clinical relevance of these in vitro findings.
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Authors | Dominic Dellweg, Herbert Wachtel, Ekkehard Höhn, Michael P Pieper, Thomas Barchfeld, Dieter Köhler, Thomas Glaab |
Journal | Journal of aerosol medicine and pulmonary drug delivery
(J Aerosol Med Pulm Drug Deliv)
Vol. 24
Issue 6
Pg. 285-92
(Dec 2011)
ISSN: 1941-2703 [Electronic] United States |
PMID | 21870959
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
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Chemical References |
- Aerosols
- Bronchodilator Agents
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Topics |
- Aerosols
- Bronchodilator Agents
(administration & dosage)
- Humans
- Nebulizers and Vaporizers
- Pulmonary Disease, Chronic Obstructive
(drug therapy)
- Respiration, Artificial
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