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[Inhalation of aerosolized perfluorocarbon combined with tetramethylpyrazine ameliorates hemodynamics and pulmonary histopathology in a porcine model of acute lung injury].

AbstractOBJECTIVE:
To observe the effect of inhalation of aerosolized perfluorocarbon combined with tetramethylpyrazine on the hemodynamics and histopathology in a porcine model of acute lung injury.
METHODS:
Normal adult pigs were subjected to saline lavage of the bilateral lungs to induce acute lung injury and randomized subsequently into 3 groups for treatment with inhalation of perfluorocarbon, combined inhalation of perfluorocarbon and tetramethylpyrazine, or inhalation of tetramethylpyrazine. The changes of mean arterial pressure (MAP), PetCO(2), mPAP, CVP and PAWP were recorded at different time points following the lung injury, and the lung tissues were sampled for histological observations.
RESULTS:
The MAP, mPAP, CVP and PAWP all increased significantly in the 3 groups after acute lung injury. Interventions with combined tetramethylpyrazine and perfluorocarbon inhalation significantly improved these indices as compared with inhalation of tetramethylpyrazine or perfluorocarbon alone (P<0.05). The pulmonary pathology was the mildest in the combined inhalation group, and the most severe in tetramethylpyrazine group.
CONCLUSION:
Combined inhalation of perfluorocarbon and tetramethylpyrazine can effectively improve the oxygenation, reduce pulmonary arterial pressure?and ameliorate lung pathology in pigs with acute lung injury.
AuthorsXue-mei Peng, Juan-hua Xie, Bing Shuai, Yan-lan Li, Zhong-hong Wang, Hua-dong Wang, Yan-ping Wang
JournalNan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 31 Issue 8 Pg. 1382-6 (Aug 2011) ISSN: 1673-4254 [Print] China
PMID21868329 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fluorocarbons
  • Pyrazines
  • tetramethylpyrazine
Topics
  • Acute Lung Injury (drug therapy, etiology, pathology)
  • Administration, Inhalation
  • Animals
  • Drug Therapy, Combination
  • Fluorocarbons (administration & dosage)
  • Hemodynamics (drug effects)
  • Lung (pathology)
  • Phytotherapy
  • Pyrazines (administration & dosage)
  • Swine

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