Abstract | BACKGROUND: METHODS: In the present study, we explored the association of two common PNMT promoter single-nucleotide polymorphisms (SNPs) G-367A (rs3764351) and G-161A (rs876493) and their haplotypes with the risk of essential hypertension in a Han Chinese population, using 316 pairs of age-, sex-, and geographically matched essential hypertension patients and normotensive controls. RESULTS: No significant difference in allele and genotype frequencies at either G-367A (rs3764351) or G-161A (rs876493) was observed between essential hypertension patients and normotensive controls. However, the 2-SNP AA haplotype was found significantly more common in normotensive controls than in essential hypertensive patients (P = 0.01; adjusted odds ratios, 0.17; 95% confidence interval, 0.05-0.58). CONCLUSIONS: The 2-SNP AA haplotype in the PNMT promoter is associated with decreased risk of essential hypertension in Han Chinese. This is the first evidence of an association between a PNMT promoter haplotype and the risk of essential hypertension.
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Authors | Cheng Huang, Saidan Zhang, Ke Hu, Qilin Ma, Tianlun Yang |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 24
Issue 11
Pg. 1222-6
(Nov 2011)
ISSN: 1941-7225 [Electronic] United States |
PMID | 21866188
(Publication Type: Journal Article)
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Chemical References |
- Phenylethanolamine N-Methyltransferase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Asian People
(genetics)
- Case-Control Studies
- China
(epidemiology)
- Female
- Haplotypes
(genetics)
- Humans
- Hypertension
(epidemiology, genetics)
- Male
- Middle Aged
- Phenylethanolamine N-Methyltransferase
(genetics)
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
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