Abstract | BACKGROUND: METHODS: Patients with chronic periodontitis and intraoral Porphyromonas gingivalis (P. gingivalis) and Tannerella forsythia who completed initial therapy were randomly assigned to receive SubGPAP in periodontal pockets with probing depths of 4 to 9 mm, SupraGPAP in all other shallow periodontal sites, and at mucous membranes followed by removal of calculus using curets (full-mouth GPAP) or scaling and root planing followed by coronal polishing (SRP). Patients rinsed with 0.12% chlorhexidine gluconate after debridement, and twice daily, for 2 weeks. RESULTS: All 30 patients enrolled completed the baseline, day 10, and day 90 visits. SubGPAP resulted in significantly lower total viable bacterial counts in moderate-to-deep pockets when compared to SRP immediately after debridement and at day 10 (P <0.05). Total P. gingivalis counts in the oral cavity were significantly reduced after full-mouth GPAP compared to SRP at day 90 (P <0.05). Patients' comfort levels were high for both treatments. There were no adverse events related to full-mouth GPAP. CONCLUSIONS: The results indicate that SubGPAP is more efficacious in removing subgingival biofilm in moderate-to-deep periodontal pockets than SRP. Furthermore, full-mouth GPAP may result in a beneficial shift of the oral microbiota and appears to be well tolerated.
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Authors | Thomas F Flemmig, Daniyel Arushanov, Diane Daubert, Marilynn Rothen, Gregory Mueller, Brian G Leroux |
Journal | Journal of periodontology
(J Periodontol)
Vol. 83
Issue 4
Pg. 444-52
(Apr 2012)
ISSN: 1943-3670 [Electronic] United States |
PMID | 21861637
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents, Local
- Glycine Agents
- Mouthwashes
- Powders
- chlorhexidine gluconate
- Chlorhexidine
- Glycine
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Topics |
- Adult
- Aged
- Anti-Infective Agents, Local
(therapeutic use)
- Bacterial Load
- Bacteroidaceae Infections
(therapy)
- Bacteroides
(isolation & purification)
- Biofilms
- Chlorhexidine
(analogs & derivatives, therapeutic use)
- Chronic Periodontitis
(microbiology, therapy)
- Dental Calculus
(therapy)
- Dental Prophylaxis
(methods)
- Dental Scaling
(instrumentation, methods)
- Female
- Follow-Up Studies
- Glycine
(therapeutic use)
- Glycine Agents
(therapeutic use)
- Humans
- Male
- Microbial Viability
- Middle Aged
- Mouthwashes
(therapeutic use)
- Patient Satisfaction
- Periodontal Pocket
(microbiology, therapy)
- Porphyromonas gingivalis
(isolation & purification)
- Powders
- Root Planing
(methods)
- Safety
- Subgingival Curettage
(methods)
- Treatment Outcome
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