Abstract | BACKGROUND: Gram-negative bacterial resistance to antibiotics is of increasing concern. Carbapenem resistance among strains of Klebsiella pneumoniae is a relatively new phenomenon. Resistance attributable to production of carbapenemases is notoriously difficult to combat. METHODS: Case report and review of the pertinent English-language literature. RESULTS: CONCLUSION: This is the first report of a meropenem-non-susceptible carbapenamase-positive Klebsiella pneumoniae blood stream infection treated successfully with high-dose, continuous-infusion meropenem. Application of this regimen in certain patients, such as those with mild-to-moderate renal insufficiency, may be a reasonable option for multi- drug-resistant nosocomial infections.
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Authors | Vanessa P Ho, Stephen G Jenkins, Cheguevara I Afaneh, Harma K Turbendian, David P Nicolau, Philip S Barie |
Journal | Surgical infections
(Surg Infect (Larchmt))
Vol. 12
Issue 4
Pg. 325-7
(Aug 2011)
ISSN: 1557-8674 [Electronic] United States |
PMID | 21859337
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Thienamycins
- beta-Lactamases
- beta-lactamase KPC-2, Klebsiella pneumoniae
- Meropenem
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Topics |
- Anti-Bacterial Agents
(administration & dosage, pharmacokinetics)
- Bacteremia
(drug therapy, microbiology)
- Humans
- Infusions, Intravenous
(methods)
- Klebsiella Infections
(drug therapy, microbiology)
- Klebsiella pneumoniae
(enzymology, isolation & purification)
- Male
- Meropenem
- Microbial Sensitivity Tests
- Middle Aged
- Serum
(chemistry)
- Thienamycins
(administration & dosage, pharmacokinetics)
- Treatment Outcome
- beta-Lactam Resistance
- beta-Lactamases
(metabolism)
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